FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925195004> ?p ?o ?g. }

• W2925195004 endingPage "2613" @default.
• W2925195004 startingPage "2603" @default.
• W2925195004 abstract "Optogenetics provides promising tools for the precise control of receptor-mediated cell behaviors in a spatiotemporal manner. Yet, most photoreceptors require extensive genetic manipulation and respond only to ultraviolet or visible light, which are suboptimal for in vivo applications because they do not penetrate thick tissues. Here we report a novel near-infrared light-activated DNA agonist (NIR-DA) nanodevice for nongenetic manipulation of cell signaling and phenotype in deep tissues. This nanodevice is prepared by conjugating a preinactivated DNA agonist onto the gold nanorods (AuNRs). Upon NIR light treatment, the DNA agonist is released through the localized surface plasmon resonance (LSPR)-based photothermal effect of AuNRs and becomes active. The active DNA agonist dimerizes the DNA-modified chimeric or native receptor tyrosine kinase (RTK) on cell surfaces and activates downstream signal transduction in live cells. Such NIR-DA activation of RTK signaling enables the control of cytoskeletal remodeling, cell polarization, and directional migration. Furthermore, we demonstrate that the NIR-DA system can be used in vivo to mediate RTK signaling and skeletal muscle satellite cell migration and myogenesis, which are critical cellular behaviors in the process of skeletal muscle regeneration. Thus, the NIR-DA system offers a powerful and versatile platform for exogenous modulation of deep tissues for purposes such as regenerative medicine." @default.
• W2925195004 created "2019-04-01" @default.
• W2925195004 creator A5013498569 @default.
• W2925195004 creator A5019560977 @default.
• W2925195004 creator A5032826756 @default.
• W2925195004 creator A5040415996 @default.
• W2925195004 creator A5044257190 @default.
• W2925195004 creator A5061082958 @default.
• W2925195004 creator A5073492643 @default.
• W2925195004 creator A5078126584 @default.
• W2925195004 date "2019-03-25" @default.
• W2925195004 modified "2023-10-15" @default.
• W2925195004 title "Near-Infrared Light-Activated DNA-Agonist Nanodevice for Nongenetically and Remotely Controlled Cellular Signaling and Behaviors in Live Animals" @default.
• W2925195004 cites W1639110634 @default.
• W2925195004 cites W1974132542 @default.
• W2925195004 cites W1998118119 @default.
• W2925195004 cites W1998882765 @default.
• W2925195004 cites W2025304928 @default.
• W2925195004 cites W2028415754 @default.
• W2925195004 cites W2045936365 @default.
• W2925195004 cites W2069421644 @default.
• W2925195004 cites W2070559164 @default.
• W2925195004 cites W2081758144 @default.
• W2925195004 cites W2086849056 @default.
• W2925195004 cites W2088183084 @default.
• W2925195004 cites W2118291545 @default.
• W2925195004 cites W2151366879 @default.
• W2925195004 cites W2168608847 @default.
• W2925195004 cites W2179910647 @default.
• W2925195004 cites W2267893954 @default.
• W2925195004 cites W2279631404 @default.
• W2925195004 cites W2311530920 @default.
• W2925195004 cites W2336249048 @default.
• W2925195004 cites W2405645527 @default.
• W2925195004 cites W2550242222 @default.
• W2925195004 cites W2602977838 @default.
• W2925195004 cites W2611260104 @default.
• W2925195004 cites W2614177016 @default.
• W2925195004 cites W2616534571 @default.
• W2925195004 cites W2617864331 @default.
• W2925195004 cites W2735501254 @default.
• W2925195004 cites W2765172570 @default.
• W2925195004 cites W2769209008 @default.
• W2925195004 cites W2770288947 @default.
• W2925195004 cites W2780825361 @default.
• W2925195004 cites W2782504069 @default.
• W2925195004 cites W2785325647 @default.
• W2925195004 cites W2786186674 @default.
• W2925195004 cites W2793672834 @default.
• W2925195004 cites W2794262744 @default.
• W2925195004 cites W2798088565 @default.
• W2925195004 cites W2800569219 @default.
• W2925195004 cites W2801385108 @default.
• W2925195004 cites W2807119029 @default.
• W2925195004 cites W2808792398 @default.
• W2925195004 cites W2810348271 @default.
• W2925195004 cites W2883070801 @default.
• W2925195004 cites W2883901798 @default.
• W2925195004 cites W2885856995 @default.
• W2925195004 cites W2889051408 @default.
• W2925195004 cites W2889934299 @default.
• W2925195004 cites W2895946463 @default.
• W2925195004 cites W2904434219 @default.
• W2925195004 cites W4211087439 @default.
• W2925195004 doi "https://doi.org/10.1021/acs.nanolett.9b00421" @default.
• W2925195004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6530480" @default.
• W2925195004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30907088" @default.
• W2925195004 hasPublicationYear "2019" @default.
• W2925195004 type Work @default.
• W2925195004 sameAs 2925195004 @default.
• W2925195004 citedByCount "66" @default.
• W2925195004 countsByYear W29251950042019 @default.
• W2925195004 countsByYear W29251950042020 @default.
• W2925195004 countsByYear W29251950042021 @default.
• W2925195004 countsByYear W29251950042022 @default.
• W2925195004 countsByYear W29251950042023 @default.
• W2925195004 crossrefType "journal-article" @default.
• W2925195004 hasAuthorship W2925195004A5013498569 @default.
• W2925195004 hasAuthorship W2925195004A5019560977 @default.
• W2925195004 hasAuthorship W2925195004A5032826756 @default.
• W2925195004 hasAuthorship W2925195004A5040415996 @default.
• W2925195004 hasAuthorship W2925195004A5044257190 @default.
• W2925195004 hasAuthorship W2925195004A5061082958 @default.
• W2925195004 hasAuthorship W2925195004A5073492643 @default.
• W2925195004 hasAuthorship W2925195004A5078126584 @default.
• W2925195004 hasBestOaLocation W29251950042 @default.
• W2925195004 hasConcept C12554922 @default.
• W2925195004 hasConcept C171250308 @default.
• W2925195004 hasConcept C185592680 @default.
• W2925195004 hasConcept C192562407 @default.
• W2925195004 hasConcept C207200792 @default.
• W2925195004 hasConcept C2909374376 @default.
• W2925195004 hasConcept C3763915 @default.
• W2925195004 hasConcept C62478195 @default.
• W2925195004 hasConcept C86803240 @default.
• W2925195004 hasConcept C95444343 @default.
• W2925195004 hasConceptScore W2925195004C12554922 @default.
• W2925195004 hasConceptScore W2925195004C171250308 @default.

• next