FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925196409> ?p ?o ?g. }

• W2925196409 endingPage "1471" @default.
• W2925196409 startingPage "1471" @default.
• W2925196409 abstract "Apolipoprotein E (apoE) is mainly secreted by hepatocytes and incorporated into most plasma lipoproteins. Macrophages, which accumulate cholesterol and are critical for the development of the atherosclerotic plaque, are also an important, albeit smaller, apoE source. Distal regulatory elements control cell-specific activity of the apoE promoter: multienhancers (ME.1/2) in macrophages and hepatic control regions (HCR-1/2) in hepatocytes. A member of AP-1 cell growth regulator, c-Jun regulates the transcription of various apolipoproteins and proinflammatory molecules implicated in atherosclerosis. We aimed to investigate the effect of c-Jun on apoE expression in macrophages versus hepatocytes and to reveal the underlying molecular mechanisms. Herein we show that c-Jun had an opposite, cell-specific effect on apoE expression: downregulation in macrophages but upregulation in hepatocytes. Transient transfections using ME.2 deletion mutants and DNA pull-down (DNAP) assays showed that the inhibitory effect of c-Jun on the apoE promoter in macrophages was mediated by a functional c-Jun binding site located at 301/311 on ME.2. In hepatocytes, c-Jun overexpression strongly increased apoE expression, and this effect was due to c-Jun binding at the canonical site located at -94/-84 on the apoE proximal promoter, identified by transient transfections using apoE deletion mutants, DNAP, and chromatin immunoprecipitation assays. Overall, the dual effect of c-Jun on apoE gene expression led to decreased cholesterol efflux in macrophages resident in the atherosclerotic plaque synergized with an increased level of systemic apoE secreted by the liver to exacerbate atherogenesis." @default.
• W2925196409 created "2019-04-01" @default.
• W2925196409 creator A5015001336 @default.
• W2925196409 creator A5028981837 @default.
• W2925196409 creator A5045427467 @default.
• W2925196409 creator A5058779133 @default.
• W2925196409 creator A5073391419 @default.
• W2925196409 date "2019-03-23" @default.
• W2925196409 modified "2023-10-12" @default.
• W2925196409 title "The Opposite Effect of c-Jun Transcription Factor on Apolipoprotein E Gene Regulation in Hepatocytes and Macrophages" @default.
• W2925196409 cites W1507649645 @default.
• W2925196409 cites W1595513249 @default.
• W2925196409 cites W1859624620 @default.
• W2925196409 cites W1920171370 @default.
• W2925196409 cites W1967004332 @default.
• W2925196409 cites W1973712332 @default.
• W2925196409 cites W1983430442 @default.
• W2925196409 cites W1986647163 @default.
• W2925196409 cites W1988205526 @default.
• W2925196409 cites W1993643447 @default.
• W2925196409 cites W1993645278 @default.
• W2925196409 cites W1995136152 @default.
• W2925196409 cites W2000951003 @default.
• W2925196409 cites W2006500406 @default.
• W2925196409 cites W2017319919 @default.
• W2925196409 cites W2018547586 @default.
• W2925196409 cites W2037389395 @default.
• W2925196409 cites W2041511626 @default.
• W2925196409 cites W2044755530 @default.
• W2925196409 cites W2054099490 @default.
• W2925196409 cites W2056516296 @default.
• W2925196409 cites W2058744360 @default.
• W2925196409 cites W2064879068 @default.
• W2925196409 cites W2075152711 @default.
• W2925196409 cites W2077219082 @default.
• W2925196409 cites W2080690412 @default.
• W2925196409 cites W2080831516 @default.
• W2925196409 cites W2083874180 @default.
• W2925196409 cites W2094872845 @default.
• W2925196409 cites W2134010411 @default.
• W2925196409 cites W2143955562 @default.
• W2925196409 cites W2161579926 @default.
• W2925196409 cites W2165308409 @default.
• W2925196409 cites W2166342119 @default.
• W2925196409 cites W2169149496 @default.
• W2925196409 cites W2597417632 @default.
• W2925196409 cites W2792012470 @default.
• W2925196409 cites W5090069 @default.
• W2925196409 doi "https://doi.org/10.3390/ijms20061471" @default.
• W2925196409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6471215" @default.
• W2925196409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30909560" @default.
• W2925196409 hasPublicationYear "2019" @default.
• W2925196409 type Work @default.
• W2925196409 sameAs 2925196409 @default.
• W2925196409 citedByCount "4" @default.
• W2925196409 countsByYear W29251964092019 @default.
• W2925196409 countsByYear W29251964092020 @default.
• W2925196409 countsByYear W29251964092021 @default.
• W2925196409 countsByYear W29251964092022 @default.
• W2925196409 crossrefType "journal-article" @default.
• W2925196409 hasAuthorship W2925196409A5015001336 @default.
• W2925196409 hasAuthorship W2925196409A5028981837 @default.
• W2925196409 hasAuthorship W2925196409A5045427467 @default.
• W2925196409 hasAuthorship W2925196409A5058779133 @default.
• W2925196409 hasAuthorship W2925196409A5073391419 @default.
• W2925196409 hasBestOaLocation W29251964091 @default.
• W2925196409 hasConcept C101762097 @default.
• W2925196409 hasConcept C104317684 @default.
• W2925196409 hasConcept C126322002 @default.
• W2925196409 hasConcept C127561419 @default.
• W2925196409 hasConcept C134320426 @default.
• W2925196409 hasConcept C150194340 @default.
• W2925196409 hasConcept C153911025 @default.
• W2925196409 hasConcept C164027704 @default.
• W2925196409 hasConcept C185592680 @default.
• W2925196409 hasConcept C203014093 @default.
• W2925196409 hasConcept C2776914184 @default.
• W2925196409 hasConcept C2778163477 @default.
• W2925196409 hasConcept C2779087070 @default.
• W2925196409 hasConcept C2779134260 @default.
• W2925196409 hasConcept C55493867 @default.
• W2925196409 hasConcept C57089818 @default.
• W2925196409 hasConcept C62746215 @default.
• W2925196409 hasConcept C71924100 @default.
• W2925196409 hasConcept C86339819 @default.
• W2925196409 hasConcept C86803240 @default.
• W2925196409 hasConcept C95444343 @default.
• W2925196409 hasConceptScore W2925196409C101762097 @default.
• W2925196409 hasConceptScore W2925196409C104317684 @default.
• W2925196409 hasConceptScore W2925196409C126322002 @default.
• W2925196409 hasConceptScore W2925196409C127561419 @default.
• W2925196409 hasConceptScore W2925196409C134320426 @default.
• W2925196409 hasConceptScore W2925196409C150194340 @default.
• W2925196409 hasConceptScore W2925196409C153911025 @default.
• W2925196409 hasConceptScore W2925196409C164027704 @default.
• W2925196409 hasConceptScore W2925196409C185592680 @default.
• W2925196409 hasConceptScore W2925196409C203014093 @default.
• W2925196409 hasConceptScore W2925196409C2776914184 @default.

• next