Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925237549> ?p ?o ?g. }
- W2925237549 endingPage "1271" @default.
- W2925237549 startingPage "1260" @default.
- W2925237549 abstract "Abstract Around 80% of nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC), still studies evaluating the efficacy of chemopreventive agents during early stage/s of BCC development are lacking. Accordingly, utilizing the well‐established patched (Ptch)+/− mouse model of ultraviolet B (UVB) radiation‐induced BCC formation, we excised skin samples from UVB exposed Ptch+/− and Ptch+/+ mice before tumor formation to study the promotion/progression of BCC and to determine the efficacy and target/s of silibinin, a well‐known skin cancer chemopreventive agent. UVB exposure for 1 month increased the number of mast cells in Ptch+/− mice by ~48% ( P < 0.05), which was completely inhibited by silibinin. Polymerase chain reaction profiler array analysis of skin samples showed strong molecular differences between Ptch+/+ and Ptch+/− mice which were either unexposed or UVB irradiated+/− silibinin treatment. Most notably, silibinin treatment significant decreased the expression of BMP‐2, Bbc3, PUMA, and Ccnd1 in Ptch+/− mice irradiated with silibinin + UVB. Additional studies showed that silibinin targets UVB‐induced expression of bone morphogenetic protein 2 (BMP‐2) in Ptch+/− mouse skin. Last, our studies found that silibinin strongly attenuates UVB‐induced BMP‐2 expression and DNA damage in Ptch+/− mouse skin ex vivo only after single UVB exposure. Together, our results suggest a possible role of mast cell recruitment and BMP‐2 activation in the early stages of BCC development; these are strongly inhibited by silibinin suggesting its possible chemopreventive efficacy against BCC formation in long‐term UVB exposure regimen." @default.
- W2925237549 created "2019-04-01" @default.
- W2925237549 creator A5007029060 @default.
- W2925237549 creator A5027734680 @default.
- W2925237549 creator A5032064580 @default.
- W2925237549 creator A5048444823 @default.
- W2925237549 creator A5059572873 @default.
- W2925237549 creator A5085117294 @default.
- W2925237549 date "2019-03-25" @default.
- W2925237549 modified "2023-10-14" @default.
- W2925237549 title "Silibinin inhibits ultraviolet B radiation‐induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/−) mouse model of basal cell carcinoma" @default.
- W2925237549 cites W1571019260 @default.
- W2925237549 cites W1971119095 @default.
- W2925237549 cites W1975321984 @default.
- W2925237549 cites W1983341583 @default.
- W2925237549 cites W1984791645 @default.
- W2925237549 cites W1995302047 @default.
- W2925237549 cites W2000039710 @default.
- W2925237549 cites W2001155940 @default.
- W2925237549 cites W2011831743 @default.
- W2925237549 cites W2014218119 @default.
- W2925237549 cites W2019736561 @default.
- W2925237549 cites W2021466957 @default.
- W2925237549 cites W2022916583 @default.
- W2925237549 cites W2025310342 @default.
- W2925237549 cites W2027515943 @default.
- W2925237549 cites W2034058906 @default.
- W2925237549 cites W2039404256 @default.
- W2925237549 cites W2045553766 @default.
- W2925237549 cites W2048142624 @default.
- W2925237549 cites W2052057632 @default.
- W2925237549 cites W2052409564 @default.
- W2925237549 cites W2067164920 @default.
- W2925237549 cites W2067769910 @default.
- W2925237549 cites W2079268771 @default.
- W2925237549 cites W2081214164 @default.
- W2925237549 cites W2092924359 @default.
- W2925237549 cites W2109145164 @default.
- W2925237549 cites W2110174461 @default.
- W2925237549 cites W2125652675 @default.
- W2925237549 cites W2131193868 @default.
- W2925237549 cites W2134139127 @default.
- W2925237549 cites W2137615558 @default.
- W2925237549 cites W2149880101 @default.
- W2925237549 cites W2153861174 @default.
- W2925237549 cites W2159202779 @default.
- W2925237549 cites W2168011206 @default.
- W2925237549 cites W2171796464 @default.
- W2925237549 cites W2302244837 @default.
- W2925237549 cites W2331286807 @default.
- W2925237549 cites W2581043900 @default.
- W2925237549 doi "https://doi.org/10.1002/mc.23008" @default.
- W2925237549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548631" @default.
- W2925237549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30912211" @default.
- W2925237549 hasPublicationYear "2019" @default.
- W2925237549 type Work @default.
- W2925237549 sameAs 2925237549 @default.
- W2925237549 citedByCount "5" @default.
- W2925237549 countsByYear W29252375492020 @default.
- W2925237549 countsByYear W29252375492021 @default.
- W2925237549 countsByYear W29252375492022 @default.
- W2925237549 crossrefType "journal-article" @default.
- W2925237549 hasAuthorship W2925237549A5007029060 @default.
- W2925237549 hasAuthorship W2925237549A5027734680 @default.
- W2925237549 hasAuthorship W2925237549A5032064580 @default.
- W2925237549 hasAuthorship W2925237549A5048444823 @default.
- W2925237549 hasAuthorship W2925237549A5059572873 @default.
- W2925237549 hasAuthorship W2925237549A5085117294 @default.
- W2925237549 hasBestOaLocation W29252375492 @default.
- W2925237549 hasConcept C121608353 @default.
- W2925237549 hasConcept C2777130413 @default.
- W2925237549 hasConcept C2777789703 @default.
- W2925237549 hasConcept C2777994357 @default.
- W2925237549 hasConcept C502942594 @default.
- W2925237549 hasConcept C54355233 @default.
- W2925237549 hasConcept C62478195 @default.
- W2925237549 hasConcept C86803240 @default.
- W2925237549 hasConcept C88498014 @default.
- W2925237549 hasConcept C95444343 @default.
- W2925237549 hasConcept C98274493 @default.
- W2925237549 hasConceptScore W2925237549C121608353 @default.
- W2925237549 hasConceptScore W2925237549C2777130413 @default.
- W2925237549 hasConceptScore W2925237549C2777789703 @default.
- W2925237549 hasConceptScore W2925237549C2777994357 @default.
- W2925237549 hasConceptScore W2925237549C502942594 @default.
- W2925237549 hasConceptScore W2925237549C54355233 @default.
- W2925237549 hasConceptScore W2925237549C62478195 @default.
- W2925237549 hasConceptScore W2925237549C86803240 @default.
- W2925237549 hasConceptScore W2925237549C88498014 @default.
- W2925237549 hasConceptScore W2925237549C95444343 @default.
- W2925237549 hasConceptScore W2925237549C98274493 @default.
- W2925237549 hasFunder F4320323807 @default.
- W2925237549 hasIssue "7" @default.
- W2925237549 hasLocation W29252375491 @default.
- W2925237549 hasLocation W29252375492 @default.
- W2925237549 hasLocation W29252375493 @default.
- W2925237549 hasOpenAccess W2925237549 @default.
- W2925237549 hasPrimaryLocation W29252375491 @default.