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• W2925533307 abstract "Abstract The pharmacokinetics and bioavailability of levamisole were determined in red‐eared slider turtles after single intravenous ( IV ), intramuscular ( IM ), and subcutaneous ( SC ) administration. Nine turtles received levamisole (10 mg/kg) by each route in a three‐way crossover design with a washout period of 30 days. Blood samples were collected at time 0 (pretreatment), and at 0.25, 0.5, 1, 1.5, 3, 6, 9, 12, 18, 24, 36, and 48 hr after drug administration. Plasma levamisole concentrations were determined by a high‐performance liquid chromatography assay. Data were analyzed by noncompartmental methods. The mean elimination half‐life was 5.00, 7.88, and 9.43 hr for IV , IM , and SC routes, respectively. The total clearance and volume of distribution at steady state for the IV route were 0.14 L hr −1 kg −1 and 0.81 L/kg, respectively. For the IM and SC routes, the peak plasma concentration was 9.63 and 10.51 μg/ml, respectively, with 0.5 hr of T max . The bioavailability was 93.03 and 115.25% for the IM and SC routes, respectively. The IM and SC route of levamisole, which showed the high bioavailability and long t 1/2 ʎz , can be recommended as an effective way for treating nematodes in turtles." @default.
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• W2925533307 date "2019-04-01" @default.
• W2925533307 modified "2023-09-30" @default.
• W2925533307 title "Pharmacokinetics of levamisole in the red‐eared slider turtles ( <i>Trachemys scripta elegans</i> )" @default.
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• W2925533307 doi "https://doi.org/10.1111/jvp.12763" @default.
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