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- W2925686619 abstract "Abstract Developing hierarchical supramolecular structures is important for better understanding of various biological functions and possibly generating new materials for biomedical applications. Herein, we report the first examples of functional vesicles derived from cationic spherical organic molecules ( C 1 ‐ C 3 ) which were readily synthesized by reacting a C 3 ‐symmetric tris‐benzimmidazole derivative (possessing a 1,3,5‐ethyl substituted aromatic core) with 1,3,5‐substituted tris‐bromomethyl benzene derivatives. Vesicle formation by C 1 ‐ C 3 was probed by high‐resolution microscopy (TEM and AFM), dynamic light scattering (DLS) and fluorescence microscopic imaging of calcein‐loaded vesicles. One of the vesicles [ Vesicle(C 3 ) ] displayed the ability to load the anticancer drug doxorubicin ( DOX ). The drug was subsequently released from DOX@Vesicle(C 3 ) in a stimuli‐responsive manner in presence of the well‐known vesicle destroyer Triton X‐100 , as revealed by in vitro cell migration assay carried out on a highly aggressive human breast cancer cell line ( MDA‐MB‐231 )." @default.
- W2925686619 created "2019-04-11" @default.
- W2925686619 creator A5035368809 @default.
- W2925686619 creator A5043168049 @default.
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- W2925686619 date "2019-04-26" @default.
- W2925686619 modified "2023-10-16" @default.
- W2925686619 title "Self‐Assembly of Spherical Organic Molecules to Form Hollow Vesicular Structures in Water for Encapsulation of an Anticancer Drug and Its Release" @default.
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- W2925686619 doi "https://doi.org/10.1002/asia.201900211" @default.
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