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- W2925821424 abstract "Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was designed for testing patients with amyotrophic lateral sclerosis (ALS), a multi-system neurodegenerative disease characterized by progressive physical disability. In this study, we aim to explore the potential brain microstructural substrates associated with performance on ECAS in the early stages of ALS, using a whole-brain tract-based spatial statistics diffusion tensor imaging approach. Thirty-six non-demented ALS patients, assessed using ECAS, and 35 age-, sex- and education-matched healthy controls underwent magnetic resonance imaging at 3 Tesla. The ALS patients showed decreased fractional anisotropy (FA) in the cortico-spinal tracts and corpus callosum (CC) and significant association between verbal fluency score, among ALS-specific ECAS scores, and FA measures in several long association fiber tracts in the frontal, temporal and parietal lobes. Furthermore, the ALS non-specific total score was inversely related to axial diffusivity (AD) in the mediodorsal nucleus of the thalamus, with more extended areas of correlation in the CC, when considering only the memory subscore. Our results point towards microstructural degeneration across motor and extra-motor areas in ALS, underlining that alterations in verbal fluency performances may be related to impairment of frontotemporal connectivity, while alterations of memory may be associated with damage of thalamocortical circuits." @default.
- W2925821424 created "2019-04-11" @default.
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- W2925821424 date "2019-06-01" @default.
- W2925821424 modified "2023-10-17" @default.
- W2925821424 title "Microstructural correlates of Edinburgh Cognitive and Behavioural ALS Screen (ECAS) changes in amyotrophic lateral sclerosis" @default.
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- W2925821424 cites W1975746998 @default.
- W2925821424 cites W1975947178 @default.
- W2925821424 cites W1992875797 @default.
- W2925821424 cites W1995963457 @default.
- W2925821424 cites W2004341548 @default.
- W2925821424 cites W2005977598 @default.
- W2925821424 cites W2009204038 @default.
- W2925821424 cites W2009837079 @default.
- W2925821424 cites W2015852104 @default.
- W2925821424 cites W2019680509 @default.
- W2925821424 cites W2019706623 @default.
- W2925821424 cites W2021577051 @default.
- W2925821424 cites W2022856329 @default.
- W2925821424 cites W2029688109 @default.
- W2925821424 cites W2034101864 @default.
- W2925821424 cites W2039170261 @default.
- W2925821424 cites W2045237617 @default.
- W2925821424 cites W2053855542 @default.
- W2925821424 cites W2057928592 @default.
- W2925821424 cites W2062118081 @default.
- W2925821424 cites W2064490318 @default.
- W2925821424 cites W2073987119 @default.
- W2925821424 cites W2081237186 @default.
- W2925821424 cites W2084186659 @default.
- W2925821424 cites W2084549787 @default.
- W2925821424 cites W2085012903 @default.
- W2925821424 cites W2087385982 @default.
- W2925821424 cites W2091937474 @default.
- W2925821424 cites W2096410786 @default.
- W2925821424 cites W2096790309 @default.
- W2925821424 cites W2097345043 @default.
- W2925821424 cites W2108381339 @default.
- W2925821424 cites W2111676303 @default.
- W2925821424 cites W2120459154 @default.
- W2925821424 cites W2128030851 @default.
- W2925821424 cites W2134939203 @default.
- W2925821424 cites W2135074994 @default.
- W2925821424 cites W2140424820 @default.
- W2925821424 cites W2140506633 @default.
- W2925821424 cites W2150667092 @default.
- W2925821424 cites W2152384075 @default.
- W2925821424 cites W2152493933 @default.
- W2925821424 cites W2152778442 @default.
- W2925821424 cites W2161938104 @default.
- W2925821424 cites W2163212471 @default.
- W2925821424 cites W2166434298 @default.
- W2925821424 cites W2167893510 @default.
- W2925821424 cites W2170769789 @default.
- W2925821424 cites W2258395286 @default.
- W2925821424 cites W2297401979 @default.
- W2925821424 cites W2338131205 @default.
- W2925821424 cites W2345197504 @default.
- W2925821424 cites W2373628738 @default.
- W2925821424 cites W2524757984 @default.
- W2925821424 cites W2548356313 @default.
- W2925821424 cites W2549199021 @default.
- W2925821424 cites W2558917240 @default.
- W2925821424 cites W2562172900 @default.
- W2925821424 cites W2573837084 @default.
- W2925821424 cites W2597661242 @default.
- W2925821424 cites W2606330717 @default.
- W2925821424 cites W2745159796 @default.
- W2925821424 cites W2761924535 @default.
- W2925821424 cites W2769269450 @default.
- W2925821424 cites W2769684783 @default.
- W2925821424 cites W2778854905 @default.
- W2925821424 cites W2786686080 @default.
- W2925821424 cites W2790562368 @default.
- W2925821424 cites W2790994398 @default.
- W2925821424 cites W2791301389 @default.
- W2925821424 cites W2796395588 @default.
- W2925821424 cites W2804959296 @default.
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- W2925821424 doi "https://doi.org/10.1016/j.pscychresns.2019.04.001" @default.
- W2925821424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30987770" @default.
- W2925821424 hasPublicationYear "2019" @default.
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