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• W2925943906 abstract "Altered production of cytokines is believed to contribute to early childhood susceptibility to infection. The aim of this study was to get further insight into the developmental patterns of cytokine responses from birth to adulthood. The expression levels of 13 cytokines were compared in the supernatants of phytohemaggluttinin (PHA)-stimulated whole blood from healthy neonates (cord blood, n = 8), infants ( < 1-year–old, n = 20), and school-aged children (3–15 y; n = 20). Five adults were used as reference. While Th1, Th2, and Th17 cytokine levels increased progressively from birth to childhood (Mann–Whitney, p < 0.003), high IL-10 secretion at birth dropped to low adult levels in infants (p < 0.004) such that a negative correlation between IL-10 and Th1, Th2, and Th17 cytokine levels at birth (Spearman’s correlation, r < −0.70, p < 0.01) converted to a positive correlation in infants (r > 0.60, p < 0.001). Finally, high IL-2, IL-7, and Granulocyte-Colony Stimulating factor (G-CSF) cytokine levels at birth decreased steadily over the first year of life (Mann–Whitney, p ≤ 0.001). The most noticeable result of the study is the rapid shift from enhanced IL-10 secretion capacity at birth toward balanced IL-10/Th1/Th2/Th17 cytokine levels early in life. This change appears an essential precondition to fight pathogens and at the same time to avoid overwhelming inflammatory reactions." @default.
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• W2925943906 date "2019-03-31" @default.
• W2925943906 modified "2023-10-17" @default.
• W2925943906 title "Ontogeny of cytokine responses to PHA from birth to adulthood" @default.
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• W2925943906 doi "https://doi.org/10.1038/s41390-019-0383-y" @default.
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