Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925993304> ?p ?o ?g. }
- W2925993304 abstract "Abstract We have isolated Hypoculoside, a new glycosidic amino alcohol lipid from the fungus Acremonium sp. F2434 belonging to the order Hypocreales and determined its structure by 2D-NMR (Nuclear Magnetic Resonance) spectroscopy. Hypoculoside has antifungal, antibacterial and cytotoxic activities. Homozygous profiling (HOP) of hypoculoside in Saccharomyces cerevisiae (budding yeast) revealed that several mutants defective in vesicular trafficking and vacuolar protein transport are sensitive to hypoculoside. Staining of budding yeast cells with the styryl dye FM4-64 indicated that hypoculoside damaged the vacuolar structure. Furthermore, the propidium iodide (PI) uptake assay showed that hypoculoside disrupted the plasma membrane integrity of budding yeast cells. Interestingly, the glycosidic moiety of hypoculoside is required for its deleterious effect on growth, vacuoles and plasma membrane of budding yeast cells." @default.
- W2925993304 created "2019-04-11" @default.
- W2925993304 creator A5005077255 @default.
- W2925993304 creator A5005547579 @default.
- W2925993304 creator A5009235099 @default.
- W2925993304 creator A5011641875 @default.
- W2925993304 creator A5020782789 @default.
- W2925993304 creator A5026460123 @default.
- W2925993304 creator A5032049966 @default.
- W2925993304 creator A5037476667 @default.
- W2925993304 creator A5051554901 @default.
- W2925993304 creator A5061709008 @default.
- W2925993304 creator A5068224828 @default.
- W2925993304 creator A5072349549 @default.
- W2925993304 creator A5076727194 @default.
- W2925993304 date "2019-01-24" @default.
- W2925993304 modified "2023-09-27" @default.
- W2925993304 title "Hypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells" @default.
- W2925993304 cites W1535433473 @default.
- W2925993304 cites W1536374844 @default.
- W2925993304 cites W1969353942 @default.
- W2925993304 cites W1969521143 @default.
- W2925993304 cites W1979351994 @default.
- W2925993304 cites W1982890700 @default.
- W2925993304 cites W1997678377 @default.
- W2925993304 cites W2007219870 @default.
- W2925993304 cites W2018243099 @default.
- W2925993304 cites W2019215631 @default.
- W2925993304 cites W2021196811 @default.
- W2925993304 cites W2023250574 @default.
- W2925993304 cites W2023518810 @default.
- W2925993304 cites W2030966943 @default.
- W2925993304 cites W2031435451 @default.
- W2925993304 cites W2032315776 @default.
- W2925993304 cites W2034607874 @default.
- W2925993304 cites W2039284674 @default.
- W2925993304 cites W2043489409 @default.
- W2925993304 cites W2059237249 @default.
- W2925993304 cites W2075428762 @default.
- W2925993304 cites W2078807391 @default.
- W2925993304 cites W2079165366 @default.
- W2925993304 cites W2089543257 @default.
- W2925993304 cites W2104950526 @default.
- W2925993304 cites W2105085077 @default.
- W2925993304 cites W2107265966 @default.
- W2925993304 cites W2121907028 @default.
- W2925993304 cites W2123590581 @default.
- W2925993304 cites W2126505667 @default.
- W2925993304 cites W2133465414 @default.
- W2925993304 cites W2136803224 @default.
- W2925993304 cites W2142437744 @default.
- W2925993304 cites W2142585918 @default.
- W2925993304 cites W2158217645 @default.
- W2925993304 cites W2160146722 @default.
- W2925993304 cites W2333882210 @default.
- W2925993304 cites W2334903862 @default.
- W2925993304 cites W2384524327 @default.
- W2925993304 cites W2765401105 @default.
- W2925993304 cites W2768617092 @default.
- W2925993304 cites W2793028243 @default.
- W2925993304 cites W2799524357 @default.
- W2925993304 cites W2807470982 @default.
- W2925993304 cites W2820974015 @default.
- W2925993304 doi "https://doi.org/10.1038/s41598-018-35979-z" @default.
- W2925993304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345779" @default.
- W2925993304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30679518" @default.
- W2925993304 hasPublicationYear "2019" @default.
- W2925993304 type Work @default.
- W2925993304 sameAs 2925993304 @default.
- W2925993304 citedByCount "6" @default.
- W2925993304 countsByYear W29259933042019 @default.
- W2925993304 countsByYear W29259933042020 @default.
- W2925993304 countsByYear W29259933042022 @default.
- W2925993304 crossrefType "journal-article" @default.
- W2925993304 hasAuthorship W2925993304A5005077255 @default.
- W2925993304 hasAuthorship W2925993304A5005547579 @default.
- W2925993304 hasAuthorship W2925993304A5009235099 @default.
- W2925993304 hasAuthorship W2925993304A5011641875 @default.
- W2925993304 hasAuthorship W2925993304A5020782789 @default.
- W2925993304 hasAuthorship W2925993304A5026460123 @default.
- W2925993304 hasAuthorship W2925993304A5032049966 @default.
- W2925993304 hasAuthorship W2925993304A5037476667 @default.
- W2925993304 hasAuthorship W2925993304A5051554901 @default.
- W2925993304 hasAuthorship W2925993304A5061709008 @default.
- W2925993304 hasAuthorship W2925993304A5068224828 @default.
- W2925993304 hasAuthorship W2925993304A5072349549 @default.
- W2925993304 hasAuthorship W2925993304A5076727194 @default.
- W2925993304 hasBestOaLocation W29259933041 @default.
- W2925993304 hasConcept C102568950 @default.
- W2925993304 hasConcept C185592680 @default.
- W2925993304 hasConcept C190062978 @default.
- W2925993304 hasConcept C190283241 @default.
- W2925993304 hasConcept C2775934118 @default.
- W2925993304 hasConcept C2777576037 @default.
- W2925993304 hasConcept C2779222958 @default.
- W2925993304 hasConcept C31573885 @default.
- W2925993304 hasConcept C55493867 @default.
- W2925993304 hasConcept C86803240 @default.
- W2925993304 hasConcept C95444343 @default.
- W2925993304 hasConceptScore W2925993304C102568950 @default.