FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2926174855> ?p ?o ?g. }

• W2926174855 endingPage "408" @default.
• W2926174855 startingPage "393" @default.
• W2926174855 abstract "Drug doses are often titrated upon their clinical effects (e.g., blood pressure). Unfortunately, for many drugs there is no direct, clinical read-out to estimate dose adequateness. Alternatively, drug dosing is based on the maximum tolerated dose approach or therapeutic drug monitoring. However, the concentration-response curves may be flattened or bell-shaped as suggested for some ‘biologicals’. Together, these aspects raise the question why drug dosing is not individualized by pharmacodynamic monitoring. Evaluating the effects of drugs at their pharmacological target or meaningful biomarkers might indicate nonresponders, objectively quantify the maximum molecular effect and thus restrict overdose and underdosing. This review outlines the theory and biological or technical prerequisites for biomarker-based pharmacodynamic monitoring, and highlights selected examples from different fields of clinical medicine." @default.
• W2926174855 created "2019-04-11" @default.
• W2926174855 creator A5020225544 @default.
• W2926174855 creator A5049313911 @default.
• W2926174855 date "2019-04-01" @default.
• W2926174855 modified "2023-09-25" @default.
• W2926174855 title "Pharmacodynamic monitoring using biomarkers to individualize pharmacotherapy" @default.
• W2926174855 cites W1495287184 @default.
• W2926174855 cites W1495576061 @default.
• W2926174855 cites W1502501798 @default.
• W2926174855 cites W1549144603 @default.
• W2926174855 cites W1591811204 @default.
• W2926174855 cites W1603230122 @default.
• W2926174855 cites W1787102412 @default.
• W2926174855 cites W1953300272 @default.
• W2926174855 cites W1959229688 @default.
• W2926174855 cites W1967318659 @default.
• W2926174855 cites W1968886697 @default.
• W2926174855 cites W1971278669 @default.
• W2926174855 cites W1971341070 @default.
• W2926174855 cites W1974506402 @default.
• W2926174855 cites W1974698157 @default.
• W2926174855 cites W1977999028 @default.
• W2926174855 cites W1982913546 @default.
• W2926174855 cites W1983762272 @default.
• W2926174855 cites W1983981808 @default.
• W2926174855 cites W1984087017 @default.
• W2926174855 cites W1988350523 @default.
• W2926174855 cites W1989082515 @default.
• W2926174855 cites W1989813987 @default.
• W2926174855 cites W1992199928 @default.
• W2926174855 cites W1993186086 @default.
• W2926174855 cites W1994924651 @default.
• W2926174855 cites W2000980666 @default.
• W2926174855 cites W2002189121 @default.
• W2926174855 cites W2002514824 @default.
• W2926174855 cites W2006202974 @default.
• W2926174855 cites W2009915820 @default.
• W2926174855 cites W2017088015 @default.
• W2926174855 cites W2017322644 @default.
• W2926174855 cites W2017666800 @default.
• W2926174855 cites W2024893955 @default.
• W2926174855 cites W2025010639 @default.
• W2926174855 cites W2032902988 @default.
• W2926174855 cites W2034276359 @default.
• W2926174855 cites W2034660243 @default.
• W2926174855 cites W2035643919 @default.
• W2926174855 cites W2039941561 @default.
• W2926174855 cites W2041327030 @default.
• W2926174855 cites W2043572207 @default.
• W2926174855 cites W2045296441 @default.
• W2926174855 cites W2045556200 @default.
• W2926174855 cites W2049320716 @default.
• W2926174855 cites W2049840779 @default.
• W2926174855 cites W2050154180 @default.
• W2926174855 cites W2056810545 @default.
• W2926174855 cites W2062112600 @default.
• W2926174855 cites W2067194535 @default.
• W2926174855 cites W2072069319 @default.
• W2926174855 cites W2072267073 @default.
• W2926174855 cites W2074567872 @default.
• W2926174855 cites W2079262950 @default.
• W2926174855 cites W2081375534 @default.
• W2926174855 cites W2085518069 @default.
• W2926174855 cites W2085657212 @default.
• W2926174855 cites W2087002521 @default.
• W2926174855 cites W2092838310 @default.
• W2926174855 cites W2097681404 @default.
• W2926174855 cites W2099185967 @default.
• W2926174855 cites W2107611068 @default.
• W2926174855 cites W2113152550 @default.
• W2926174855 cites W2113512182 @default.
• W2926174855 cites W2114336081 @default.
• W2926174855 cites W2124720938 @default.
• W2926174855 cites W2126275851 @default.
• W2926174855 cites W2127303736 @default.
• W2926174855 cites W2127874262 @default.
• W2926174855 cites W2134928243 @default.
• W2926174855 cites W2138722825 @default.
• W2926174855 cites W2139740540 @default.
• W2926174855 cites W2141393790 @default.
• W2926174855 cites W2141716584 @default.
• W2926174855 cites W2142872889 @default.
• W2926174855 cites W2145066076 @default.
• W2926174855 cites W2145067755 @default.
• W2926174855 cites W2145835533 @default.
• W2926174855 cites W2145977358 @default.
• W2926174855 cites W2149411747 @default.
• W2926174855 cites W2151520766 @default.
• W2926174855 cites W2152345375 @default.
• W2926174855 cites W2152466022 @default.
• W2926174855 cites W2154263136 @default.
• W2926174855 cites W2156131531 @default.
• W2926174855 cites W2157543984 @default.
• W2926174855 cites W2157769714 @default.
• W2926174855 cites W2168179372 @default.
• W2926174855 cites W2169228559 @default.
• W2926174855 cites W2171497508 @default.

• next