Matches in SemOpenAlex for { <https://semopenalex.org/work/W292618297> ?p ?o ?g. }
- W292618297 abstract "Administration of 17-βestradiol (E2) with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) can induce ovulation in estrogen-deficient (ArKO) mice; nevertheless, ovulatory efficiency and rate are low. In this study, effects of insulin on the ovulatory responses were investigated. In ArKO ovary, hCG signal was found to be transmitted in an uncoordinated manner when phosphorylation levels of signaling molecules are examined. Co-administration of insulin with hCG improved the transmission of hCG signal as well as the ovulatory efficiency in ArKO mice. It also improved the ovulatory rate but far below the wild-type rate. Gene expression analysis demonstrated that Cyp11a1 and Cyp17a1 mRNAs were significantly induced 4 h after PMSG administration in the wild-type ovary, but not in ArKO ovary. Collectively, these results suggest that insulin improves ovulatory responses of ArKO mice, but it fails to ameliorate follicular dysfunctions caused possibly by an inappropriate intraovarian milieu during follicular maturation." @default.
- W292618297 created "2016-06-24" @default.
- W292618297 creator A5017697694 @default.
- W292618297 creator A5022260018 @default.
- W292618297 creator A5057541132 @default.
- W292618297 creator A5085574358 @default.
- W292618297 date "2015-08-01" @default.
- W292618297 modified "2023-10-03" @default.
- W292618297 title "Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice" @default.
- W292618297 cites W1546970785 @default.
- W292618297 cites W1708429683 @default.
- W292618297 cites W1979644229 @default.
- W292618297 cites W1982458028 @default.
- W292618297 cites W1992761385 @default.
- W292618297 cites W2005028301 @default.
- W292618297 cites W2005531798 @default.
- W292618297 cites W2009171847 @default.
- W292618297 cites W2010637356 @default.
- W292618297 cites W2027128457 @default.
- W292618297 cites W2030444886 @default.
- W292618297 cites W2033527028 @default.
- W292618297 cites W2041655797 @default.
- W292618297 cites W2043046385 @default.
- W292618297 cites W2050353370 @default.
- W292618297 cites W2059004221 @default.
- W292618297 cites W2061500513 @default.
- W292618297 cites W2068305771 @default.
- W292618297 cites W2071216145 @default.
- W292618297 cites W2076237165 @default.
- W292618297 cites W2080669943 @default.
- W292618297 cites W2085923909 @default.
- W292618297 cites W2091336289 @default.
- W292618297 cites W2097155470 @default.
- W292618297 cites W2103963876 @default.
- W292618297 cites W2104673121 @default.
- W292618297 cites W2106395552 @default.
- W292618297 cites W2110365626 @default.
- W292618297 cites W2117082199 @default.
- W292618297 cites W2118506472 @default.
- W292618297 cites W2119823280 @default.
- W292618297 cites W2128242453 @default.
- W292618297 cites W2129482290 @default.
- W292618297 cites W2135067530 @default.
- W292618297 cites W2141167215 @default.
- W292618297 cites W2147196233 @default.
- W292618297 cites W2147912605 @default.
- W292618297 cites W2152625930 @default.
- W292618297 cites W2154880208 @default.
- W292618297 cites W2166188229 @default.
- W292618297 cites W2168275924 @default.
- W292618297 cites W2169538778 @default.
- W292618297 cites W2474761801 @default.
- W292618297 cites W1984508788 @default.
- W292618297 doi "https://doi.org/10.1016/j.mce.2015.04.027" @default.
- W292618297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25957088" @default.
- W292618297 hasPublicationYear "2015" @default.
- W292618297 type Work @default.
- W292618297 sameAs 292618297 @default.
- W292618297 citedByCount "3" @default.
- W292618297 countsByYear W2926182972016 @default.
- W292618297 countsByYear W2926182972017 @default.
- W292618297 countsByYear W2926182972018 @default.
- W292618297 crossrefType "journal-article" @default.
- W292618297 hasAuthorship W292618297A5017697694 @default.
- W292618297 hasAuthorship W292618297A5022260018 @default.
- W292618297 hasAuthorship W292618297A5057541132 @default.
- W292618297 hasAuthorship W292618297A5085574358 @default.
- W292618297 hasConcept C126322002 @default.
- W292618297 hasConcept C134018914 @default.
- W292618297 hasConcept C187785154 @default.
- W292618297 hasConcept C2775948956 @default.
- W292618297 hasConcept C2777164284 @default.
- W292618297 hasConcept C2777702977 @default.
- W292618297 hasConcept C2778324911 @default.
- W292618297 hasConcept C2778782382 @default.
- W292618297 hasConcept C2779306644 @default.
- W292618297 hasConcept C71315377 @default.
- W292618297 hasConcept C71924100 @default.
- W292618297 hasConcept C86803240 @default.
- W292618297 hasConceptScore W292618297C126322002 @default.
- W292618297 hasConceptScore W292618297C134018914 @default.
- W292618297 hasConceptScore W292618297C187785154 @default.
- W292618297 hasConceptScore W292618297C2775948956 @default.
- W292618297 hasConceptScore W292618297C2777164284 @default.
- W292618297 hasConceptScore W292618297C2777702977 @default.
- W292618297 hasConceptScore W292618297C2778324911 @default.
- W292618297 hasConceptScore W292618297C2778782382 @default.
- W292618297 hasConceptScore W292618297C2779306644 @default.
- W292618297 hasConceptScore W292618297C71315377 @default.
- W292618297 hasConceptScore W292618297C71924100 @default.
- W292618297 hasConceptScore W292618297C86803240 @default.
- W292618297 hasFunder F4320320912 @default.
- W292618297 hasLocation W2926182971 @default.
- W292618297 hasLocation W2926182972 @default.
- W292618297 hasOpenAccess W292618297 @default.
- W292618297 hasPrimaryLocation W2926182971 @default.
- W292618297 hasRelatedWork W1984373761 @default.
- W292618297 hasRelatedWork W2002844282 @default.
- W292618297 hasRelatedWork W2012688994 @default.
- W292618297 hasRelatedWork W2014612314 @default.