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• W2926186200 startingPage "e228376" @default.
• W2926186200 abstract "A 71-year-old female patient presented with a 14-year history of slowly progressive distal limb numbness, paraesthesia and reduced vibration perception, ataxic gait and intentional tremor. Examination revealed with a length-dependent sensory neuropathy. Nerve conduction studies showed a chronic sensorimotor inflammatory demyelinating polyneuropathy. Intravenous immunoglobulin treatment (on two occasions) proved ineffective. Serum electrophoresis showed increased monoclonal IgM with kappa light chains. Anti-myelin-associated glycoprotein (MAG) levels were extremely elevated, >70 000 BTU. Bone marrow biopsy revealed 15%–20% small B cells and positive MYD88 mutation, indicative of Waldenstrom macroglobulinaemia. A diagnosis of Waldenstrom-associated anti-MAG paraprotein neuropathy with intentional (neurogenic) tremor was made. Repeat nerve conduction study showed a severe sensory demyelinating neuropathy with no axonal lesion. Treatment with rituximab was given for 1 month with minimal improvement. Repeat anti-MAG levels dropped to 53 670 BTU, with minimal clinical improvement." @default.
• W2926186200 created "2019-04-11" @default.
• W2926186200 creator A5019362957 @default.
• W2926186200 date "2019-03-01" @default.
• W2926186200 modified "2023-09-25" @default.
• W2926186200 title "Waldenstrom-associated anti-MAG paraprotein polyneuropathy with neurogenic tremor" @default.
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• W2926186200 doi "https://doi.org/10.1136/bcr-2018-228376" @default.
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