FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2926632282> ?p ?o ?g. }

• W2926632282 endingPage "111813" @default.
• W2926632282 startingPage "111813" @default.
• W2926632282 abstract "Whitmania pigra Whitman (Whitmania pigra, WP), firstly recorded in the Shennong's Herbal Classic and officially listed in the Chinese Pharmacopoeia, is a well-used cardiovascular protective traditional Chinese medicine derived from leeches. Traditional Chinese physicians prefer to prescribe the dried whole body of leech processed under high temperatures. It has been reported that dried WP remains clinically effective. However, the therapeutic mechanism has yet not be clearly elucidated.This study was designed to investigate the protective activity of the extract of WP in a high-molecular-weight dextran-induced blood hyperviscosity rat model, and to explore the role of WP in improving blood hyperviscosity related metabolic disorders and to clarify the possible mechanism of metabolic regulation.The hemorheological parameters were measured with an automated blood rheology analyzer. Hematoxylin-eosin staining was used to observe the pathological changes in aortic tissues samples. Further, a liquid chromatography-mass-spectrometry (LC-MS)-based untargeted metabolomics approach was applied to characterize the metabolic alterations.WP has evident attenuating effects on blood hyperviscosity and related metabolic disorders, and the influences are distinct from those of aspirin. The results showed that WP had good effects in reducing blood viscosity and ameliorating histopathological changes in the thoracic aorta in a high molecular weight dextran-induced blood hyperviscosity rat model. The middle dose (2.5 g raw material/kg body weight) of WP exhibited effects equivalent to aspirin (100 mg/kg) on hemorheological and histopathological parameters (P > 0.05). However, when using metabolomics profiling, we found that WP could significantly improve blood hyperviscosity-related metabolic disorders and restore metabolites to normal levels; while aspirin showed little effect. With principal component analysis and orthogonal partial least-squares discriminant analysis, WP regulated many more endogenous metabolites than aspirin. With pathway enrichment analysis, the differential endogenous metabolites were involved in cysteine and methionine metabolism, TCA cycle, arachidonic acid metabolism, etc., highlighting the metabolic reprogramming potential of WP against blood hyperviscosity-induced metabolic disorders.The study suggest that WP has a more potent effect, but a different mechanism, than aspirin in improving either blood hyperviscosity or related metabolic disorders associated with cardio- and cerebrovascular diseases." @default.
• W2926632282 created "2019-04-11" @default.
• W2926632282 creator A5002772994 @default.
• W2926632282 creator A5007348590 @default.
• W2926632282 creator A5012647424 @default.
• W2926632282 creator A5018256092 @default.
• W2926632282 creator A5024050425 @default.
• W2926632282 creator A5033391452 @default.
• W2926632282 creator A5034345217 @default.
• W2926632282 creator A5035282947 @default.
• W2926632282 creator A5042286651 @default.
• W2926632282 creator A5050564874 @default.
• W2926632282 creator A5054418300 @default.
• W2926632282 creator A5063273603 @default.
• W2926632282 creator A5072496620 @default.
• W2926632282 creator A5074498786 @default.
• W2926632282 creator A5077396200 @default.
• W2926632282 creator A5059189268 @default.
• W2926632282 date "2019-06-01" @default.
• W2926632282 modified "2023-10-15" @default.
• W2926632282 title "Leeches attenuate blood hyperviscosity and related metabolic disorders in rats differently than aspirin" @default.
• W2926632282 cites W1965222012 @default.
• W2926632282 cites W1974230760 @default.
• W2926632282 cites W1992560177 @default.
• W2926632282 cites W1998340097 @default.
• W2926632282 cites W2006640205 @default.
• W2926632282 cites W2007162680 @default.
• W2926632282 cites W2021264914 @default.
• W2926632282 cites W2028065470 @default.
• W2926632282 cites W2049681146 @default.
• W2926632282 cites W2052438916 @default.
• W2926632282 cites W2052588755 @default.
• W2926632282 cites W2056851154 @default.
• W2926632282 cites W2060083861 @default.
• W2926632282 cites W2066604440 @default.
• W2926632282 cites W2067298762 @default.
• W2926632282 cites W2077174583 @default.
• W2926632282 cites W2089532303 @default.
• W2926632282 cites W2096513239 @default.
• W2926632282 cites W2097080185 @default.
• W2926632282 cites W2107051699 @default.
• W2926632282 cites W2109216496 @default.
• W2926632282 cites W2115527168 @default.
• W2926632282 cites W2120169871 @default.
• W2926632282 cites W2126263099 @default.
• W2926632282 cites W2159420777 @default.
• W2926632282 cites W2164947554 @default.
• W2926632282 cites W2167865516 @default.
• W2926632282 cites W2192526927 @default.
• W2926632282 cites W2251443487 @default.
• W2926632282 cites W2302896244 @default.
• W2926632282 cites W2336628396 @default.
• W2926632282 cites W2356222323 @default.
• W2926632282 cites W2473231195 @default.
• W2926632282 cites W2474498474 @default.
• W2926632282 cites W2511095111 @default.
• W2926632282 cites W2513109455 @default.
• W2926632282 cites W2533367308 @default.
• W2926632282 cites W2556132128 @default.
• W2926632282 cites W2621866593 @default.
• W2926632282 cites W2769310375 @default.
• W2926632282 cites W2794175900 @default.
• W2926632282 cites W3185159732 @default.
• W2926632282 doi "https://doi.org/10.1016/j.jep.2019.03.040" @default.
• W2926632282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30910578" @default.
• W2926632282 hasPublicationYear "2019" @default.
• W2926632282 type Work @default.
• W2926632282 sameAs 2926632282 @default.
• W2926632282 citedByCount "8" @default.
• W2926632282 countsByYear W29266322822020 @default.
• W2926632282 countsByYear W29266322822021 @default.
• W2926632282 countsByYear W29266322822022 @default.
• W2926632282 countsByYear W29266322822023 @default.
• W2926632282 crossrefType "journal-article" @default.
• W2926632282 hasAuthorship W2926632282A5002772994 @default.
• W2926632282 hasAuthorship W2926632282A5007348590 @default.
• W2926632282 hasAuthorship W2926632282A5012647424 @default.
• W2926632282 hasAuthorship W2926632282A5018256092 @default.
• W2926632282 hasAuthorship W2926632282A5024050425 @default.
• W2926632282 hasAuthorship W2926632282A5033391452 @default.
• W2926632282 hasAuthorship W2926632282A5034345217 @default.
• W2926632282 hasAuthorship W2926632282A5035282947 @default.
• W2926632282 hasAuthorship W2926632282A5042286651 @default.
• W2926632282 hasAuthorship W2926632282A5050564874 @default.
• W2926632282 hasAuthorship W2926632282A5054418300 @default.
• W2926632282 hasAuthorship W2926632282A5059189268 @default.
• W2926632282 hasAuthorship W2926632282A5063273603 @default.
• W2926632282 hasAuthorship W2926632282A5072496620 @default.
• W2926632282 hasAuthorship W2926632282A5074498786 @default.
• W2926632282 hasAuthorship W2926632282A5077396200 @default.
• W2926632282 hasConcept C126322002 @default.
• W2926632282 hasConcept C142724271 @default.
• W2926632282 hasConcept C188947578 @default.
• W2926632282 hasConcept C204787440 @default.
• W2926632282 hasConcept C2776364478 @default.
• W2926632282 hasConcept C2776379591 @default.
• W2926632282 hasConcept C2776907643 @default.
• W2926632282 hasConcept C2777628954 @default.

• next