Matches in SemOpenAlex for { <https://semopenalex.org/work/W2926685280> ?p ?o ?g. }
- W2926685280 abstract "Abstract Orthohantaviruses, previously known as hantaviruses, are zoonotic viruses that can cause hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) in humans. The HPS-causing Andes virus (ANDV) and the HFRS-causing Hantaan virus (HTNV) have anti-apoptotic effects. To investigate if this represents a general feature of orthohantaviruses, we analysed the capacity of six different orthohantaviruses – belonging to three distinct phylogroups and representing both pathogenic and non-pathogenic viruses – to inhibit apoptosis in infected cells. Primary human endothelial cells were infected with ANDV, HTNV, the HFRS-causing Puumala virus (PUUV) and Seoul virus, as well as the putative non-pathogenic Prospect Hill virus and Tula virus. Infected cells were then exposed to the apoptosis-inducing chemical staurosporine or to activated human NK cells exhibiting a high cytotoxic potential. Strikingly, all orthohantaviruses inhibited apoptosis in both settings. Moreover, we show that the nucleocapsid (N) protein from all examined orthohantaviruses are potential targets for caspase-3 and granzyme B. Recombinant N protein from ANDV, PUUV and the HFRS-causing Dobrava virus strongly inhibited granzyme B activity and also, to certain extent, caspase-3 activity. Taken together, this study demonstrates that six different orthohantaviruses inhibit apoptosis, suggesting this to be a general feature of orthohantaviruses likely serving as a mechanism of viral immune evasion." @default.
- W2926685280 created "2019-04-11" @default.
- W2926685280 creator A5029123822 @default.
- W2926685280 creator A5036093713 @default.
- W2926685280 creator A5055644268 @default.
- W2926685280 creator A5091546357 @default.
- W2926685280 date "2019-01-29" @default.
- W2926685280 modified "2023-10-16" @default.
- W2926685280 title "Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells" @default.
- W2926685280 cites W1415644738 @default.
- W2926685280 cites W1566572727 @default.
- W2926685280 cites W1586514146 @default.
- W2926685280 cites W1642794090 @default.
- W2926685280 cites W1730499774 @default.
- W2926685280 cites W1801899941 @default.
- W2926685280 cites W1897525734 @default.
- W2926685280 cites W1950362618 @default.
- W2926685280 cites W1964776939 @default.
- W2926685280 cites W1968224295 @default.
- W2926685280 cites W1969045625 @default.
- W2926685280 cites W1972103057 @default.
- W2926685280 cites W1973052078 @default.
- W2926685280 cites W1973895154 @default.
- W2926685280 cites W1974804367 @default.
- W2926685280 cites W1979444649 @default.
- W2926685280 cites W1984178787 @default.
- W2926685280 cites W1984908915 @default.
- W2926685280 cites W1989578159 @default.
- W2926685280 cites W1992062133 @default.
- W2926685280 cites W1994203042 @default.
- W2926685280 cites W1996180957 @default.
- W2926685280 cites W1998857453 @default.
- W2926685280 cites W2012295912 @default.
- W2926685280 cites W2017708875 @default.
- W2926685280 cites W2017919285 @default.
- W2926685280 cites W2031213371 @default.
- W2926685280 cites W2032206556 @default.
- W2926685280 cites W2043168822 @default.
- W2926685280 cites W2045194203 @default.
- W2926685280 cites W2048455227 @default.
- W2926685280 cites W2051597633 @default.
- W2926685280 cites W2054260525 @default.
- W2926685280 cites W2072254626 @default.
- W2926685280 cites W2072617886 @default.
- W2926685280 cites W2081145901 @default.
- W2926685280 cites W2083820302 @default.
- W2926685280 cites W2084092378 @default.
- W2926685280 cites W2085188839 @default.
- W2926685280 cites W2085704521 @default.
- W2926685280 cites W2087593127 @default.
- W2926685280 cites W2091097405 @default.
- W2926685280 cites W2093875241 @default.
- W2926685280 cites W2096333094 @default.
- W2926685280 cites W2102180105 @default.
- W2926685280 cites W2107332559 @default.
- W2926685280 cites W2108767527 @default.
- W2926685280 cites W2116628551 @default.
- W2926685280 cites W2123894750 @default.
- W2926685280 cites W2125835582 @default.
- W2926685280 cites W2128230863 @default.
- W2926685280 cites W2139360111 @default.
- W2926685280 cites W2139587743 @default.
- W2926685280 cites W2143584430 @default.
- W2926685280 cites W2143872403 @default.
- W2926685280 cites W2146212816 @default.
- W2926685280 cites W2156242168 @default.
- W2926685280 cites W2158624940 @default.
- W2926685280 cites W2160092751 @default.
- W2926685280 cites W2166512255 @default.
- W2926685280 cites W2167479260 @default.
- W2926685280 cites W2171837557 @default.
- W2926685280 cites W2317338049 @default.
- W2926685280 cites W2325707043 @default.
- W2926685280 cites W2399417090 @default.
- W2926685280 cites W2421991749 @default.
- W2926685280 cites W2588059836 @default.
- W2926685280 cites W2595587791 @default.
- W2926685280 cites W2620241325 @default.
- W2926685280 cites W273142831 @default.
- W2926685280 cites W2795052338 @default.
- W2926685280 cites W2914988408 @default.
- W2926685280 cites W3289822 @default.
- W2926685280 doi "https://doi.org/10.1038/s41598-018-37446-1" @default.
- W2926685280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6351540" @default.
- W2926685280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30696898" @default.
- W2926685280 hasPublicationYear "2019" @default.
- W2926685280 type Work @default.
- W2926685280 sameAs 2926685280 @default.
- W2926685280 citedByCount "25" @default.
- W2926685280 countsByYear W29266852802019 @default.
- W2926685280 countsByYear W29266852802020 @default.
- W2926685280 countsByYear W29266852802021 @default.
- W2926685280 countsByYear W29266852802022 @default.
- W2926685280 countsByYear W29266852802023 @default.
- W2926685280 crossrefType "journal-article" @default.
- W2926685280 hasAuthorship W2926685280A5029123822 @default.
- W2926685280 hasAuthorship W2926685280A5036093713 @default.
- W2926685280 hasAuthorship W2926685280A5055644268 @default.
- W2926685280 hasAuthorship W2926685280A5091546357 @default.
- W2926685280 hasBestOaLocation W29266852801 @default.