Matches in SemOpenAlex for { <https://semopenalex.org/work/W2926695514> ?p ?o ?g. }
- W2926695514 endingPage "27" @default.
- W2926695514 startingPage "23" @default.
- W2926695514 abstract "Many experimental studies on sugar (sucrose) omitted its form of ingestion. Often their findings were mutually incompatible. A comparison of the results of the few studies that administered sugar in a single specified form suggests that the metabolic effects of sugar depend on its form of ingestion, because even 80% of calories as diluted sugar proved harmless, but only 30% of calories as undiluted sugar proved harmful. These opposite effects of sugar can be explained by the published hypothesis that evolution adapted genetically our ancestors to cope with sugar only in diluted forms, because prehistorically diluted sugar was available abundantly in fresh fruits, but undiluted sugar was inexistent. The purpose of this review, based mainly on the evolutionary interpretation of published data of physiology, is to encourage researchers to perform an unprecedented experimental study to compare the metabolic effects of diluted sugar with the effects of undiluted sugar. The data of physiology analyzed in this review suggest that the absorption of diluted sugar within the caloric range of total sugars diluted in fresh fruits is slow and calorie-constant, thus preserving blood glucose homeostasis, whereas the absorption of concentrated sugar exceeding that caloric range is rapid, which can disrupt blood glucose homeostasis. Dietary salt, which was unknown to prehistoric humans, unnaturally accelerates the absorption of sugars. This can explain the harmful effects attributed to sugar-sweetened beverages per se, because these drinks are generally co-ingested with foods containing salt, which partly yet unavoidably passes into those beverages, thereby unhealthily accelerating their absorption. Many experimental studies on sugar (sucrose) omitted its form of ingestion. Often their findings were mutually incompatible. A comparison of the results of the few studies that administered sugar in a single specified form suggests that the metabolic effects of sugar depend on its form of ingestion, because even 80% of calories as diluted sugar proved harmless, but only 30% of calories as undiluted sugar proved harmful. These opposite effects of sugar can be explained by the published hypothesis that evolution adapted genetically our ancestors to cope with sugar only in diluted forms, because prehistorically diluted sugar was available abundantly in fresh fruits, but undiluted sugar was inexistent. The purpose of this review, based mainly on the evolutionary interpretation of published data of physiology, is to encourage researchers to perform an unprecedented experimental study to compare the metabolic effects of diluted sugar with the effects of undiluted sugar. The data of physiology analyzed in this review suggest that the absorption of diluted sugar within the caloric range of total sugars diluted in fresh fruits is slow and calorie-constant, thus preserving blood glucose homeostasis, whereas the absorption of concentrated sugar exceeding that caloric range is rapid, which can disrupt blood glucose homeostasis. Dietary salt, which was unknown to prehistoric humans, unnaturally accelerates the absorption of sugars. This can explain the harmful effects attributed to sugar-sweetened beverages per se, because these drinks are generally co-ingested with foods containing salt, which partly yet unavoidably passes into those beverages, thereby unhealthily accelerating their absorption." @default.
- W2926695514 created "2019-04-11" @default.
- W2926695514 creator A5062895059 @default.
- W2926695514 date "2019-06-01" @default.
- W2926695514 modified "2023-09-25" @default.
- W2926695514 title "Evolutionary physiology shows the need for an unprecedented study on sugar" @default.
- W2926695514 cites W1615359804 @default.
- W2926695514 cites W1836053207 @default.
- W2926695514 cites W1858668303 @default.
- W2926695514 cites W1908003638 @default.
- W2926695514 cites W1931350247 @default.
- W2926695514 cites W1936679837 @default.
- W2926695514 cites W1964697781 @default.
- W2926695514 cites W1975334244 @default.
- W2926695514 cites W1978038650 @default.
- W2926695514 cites W1990065043 @default.
- W2926695514 cites W1996984354 @default.
- W2926695514 cites W2019606292 @default.
- W2926695514 cites W2019737126 @default.
- W2926695514 cites W2020794547 @default.
- W2926695514 cites W2033031318 @default.
- W2926695514 cites W2036325222 @default.
- W2926695514 cites W2036416664 @default.
- W2926695514 cites W203779165 @default.
- W2926695514 cites W2040581237 @default.
- W2926695514 cites W2041709389 @default.
- W2926695514 cites W2042160000 @default.
- W2926695514 cites W2045563911 @default.
- W2926695514 cites W2065431248 @default.
- W2926695514 cites W2066263971 @default.
- W2926695514 cites W2068044014 @default.
- W2926695514 cites W207036748 @default.
- W2926695514 cites W2074838066 @default.
- W2926695514 cites W2081962176 @default.
- W2926695514 cites W2089286734 @default.
- W2926695514 cites W2093087563 @default.
- W2926695514 cites W2098966326 @default.
- W2926695514 cites W2102838119 @default.
- W2926695514 cites W2105597558 @default.
- W2926695514 cites W2111437650 @default.
- W2926695514 cites W2113415088 @default.
- W2926695514 cites W2115321988 @default.
- W2926695514 cites W2122349669 @default.
- W2926695514 cites W2123013924 @default.
- W2926695514 cites W2128031416 @default.
- W2926695514 cites W2128042736 @default.
- W2926695514 cites W2131404723 @default.
- W2926695514 cites W2132224760 @default.
- W2926695514 cites W2133021192 @default.
- W2926695514 cites W2133472518 @default.
- W2926695514 cites W2135108753 @default.
- W2926695514 cites W2135225753 @default.
- W2926695514 cites W2135934539 @default.
- W2926695514 cites W2143611871 @default.
- W2926695514 cites W2144104522 @default.
- W2926695514 cites W2148911082 @default.
- W2926695514 cites W2162422162 @default.
- W2926695514 cites W2163147259 @default.
- W2926695514 cites W2168162793 @default.
- W2926695514 cites W2169885597 @default.
- W2926695514 cites W2186961512 @default.
- W2926695514 cites W2212737939 @default.
- W2926695514 cites W2396021667 @default.
- W2926695514 cites W2400924599 @default.
- W2926695514 cites W2411862651 @default.
- W2926695514 cites W2417139595 @default.
- W2926695514 cites W2591207079 @default.
- W2926695514 cites W2740662778 @default.
- W2926695514 cites W2740961516 @default.
- W2926695514 doi "https://doi.org/10.1016/j.clnesp.2019.03.012" @default.
- W2926695514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31060830" @default.
- W2926695514 hasPublicationYear "2019" @default.
- W2926695514 type Work @default.
- W2926695514 sameAs 2926695514 @default.
- W2926695514 citedByCount "2" @default.
- W2926695514 countsByYear W29266955142019 @default.
- W2926695514 countsByYear W29266955142020 @default.
- W2926695514 crossrefType "journal-article" @default.
- W2926695514 hasAuthorship W2926695514A5062895059 @default.
- W2926695514 hasConcept C126322002 @default.
- W2926695514 hasConcept C134018914 @default.
- W2926695514 hasConcept C185592680 @default.
- W2926695514 hasConcept C190362976 @default.
- W2926695514 hasConcept C193230392 @default.
- W2926695514 hasConcept C2777108408 @default.
- W2926695514 hasConcept C2778597767 @default.
- W2926695514 hasConcept C2778977261 @default.
- W2926695514 hasConcept C2780485761 @default.
- W2926695514 hasConcept C31903555 @default.
- W2926695514 hasConcept C40438245 @default.
- W2926695514 hasConcept C55493867 @default.
- W2926695514 hasConcept C555293320 @default.
- W2926695514 hasConcept C71924100 @default.
- W2926695514 hasConceptScore W2926695514C126322002 @default.
- W2926695514 hasConceptScore W2926695514C134018914 @default.
- W2926695514 hasConceptScore W2926695514C185592680 @default.
- W2926695514 hasConceptScore W2926695514C190362976 @default.
- W2926695514 hasConceptScore W2926695514C193230392 @default.