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• W2926710375 abstract "Psoriasis is an autoimmune chronic dermatosis that is T cell-mediated, characterized by epidermal thickening, aberrant epidermal differentiation and inflammatory infiltrates, with a dominant Th1 and Th17 profile. Additional in vitro models are required to study the complex interactions between activated T cells and skin cells, and to develop new, more effective treatments. We have therefore sought to model this psoriatic inflammation by the generation of tissue-engineered immunocompetent tissues, and we have investigated the response of activated T-cell infiltration in models produced with lesional psoriatic skin cells on major hallmarks of psoriasis. The immunocompetent lesional skin model displayed a delayed onset of epidermal differentiation, an hyperproliferation of the basal keratinocytes, a drastic increase in the secretion of proinflammatory cytokines, and a disturbed expression of key transcription factors, as observed in lesional plaques, suggesting a crucial importance of combining the pathological phenotype of cutaneous cells to T cells in order to generate a relevant model for psoriasis. Finally, we found this skin model to be responsive to methotrexate treatment, making it a valuable tool for drug development." @default.
• W2926710375 created "2019-04-11" @default.
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• W2926710375 date "2019-04-03" @default.
• W2926710375 modified "2023-10-16" @default.
• W2926710375 title "Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features" @default.
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• W2926710375 doi "https://doi.org/10.3390/ijms20071670" @default.
• W2926710375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6479293" @default.
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• W2926710375 hasPublicationYear "2019" @default.
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