Matches in SemOpenAlex for { <https://semopenalex.org/work/W2926710975> ?p ?o ?g. }
- W2926710975 abstract "Both HDAC1 and HDAC2 are class I deacetylases acting as erasers of lysine-acetyl marks on histones and non-histone proteins. Several histone deacetylase inhibitors, either endogenous to the cell, such as the ketogenic β-hydroxybutyrate metabolite, or exogenous, such as butyrate, a microbial-derived metabolite, regulate HDAC activity. Different combinations of intestinal epithelial cell (IEC)-specific Hdac1 and/or Hdac2 deletion differentially alter mucosal homeostasis in mice. Thus, HDAC1 and HDAC2 could act as sensors and transmitters of environmental signals to the mucosa. In this study, enteroid culture models deleted for Hdac1 or Hdac2 were established to determine IEC-specific function as assessed by global transcriptomic and proteomic approaches. Results show that Hdac1 or Hdac2 deficiency altered differentiation of Paneth and goblet secretory cells, which sustain physical and chemical protection barriers, and increased intermediate secretory cell precursor numbers. Furthermore, IEC Hdac1- and Hdac2-dependent common and specific biological processes were identified, including oxidation-reduction, inflammatory responses, and lipid-related metabolic processes, as well as canonical pathways and upstream regulators related to environment-dependent signaling through steroid receptor pathways, among others. These findings uncover unrecognized regulatory similarities and differences between Hdac1 and Hdac2 in IEC, and demonstrate how HDAC1 and HDAC2 may complement each other to regulate the intrinsic IEC phenotype." @default.
- W2926710975 created "2019-04-11" @default.
- W2926710975 creator A5026591351 @default.
- W2926710975 creator A5029335213 @default.
- W2926710975 creator A5029395321 @default.
- W2926710975 creator A5030574014 @default.
- W2926710975 creator A5041114334 @default.
- W2926710975 creator A5072438800 @default.
- W2926710975 creator A5080933836 @default.
- W2926710975 creator A5083981569 @default.
- W2926710975 date "2019-03-29" @default.
- W2926710975 modified "2023-10-15" @default.
- W2926710975 title "HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids" @default.
- W2926710975 cites W1551793852 @default.
- W2926710975 cites W1553155385 @default.
- W2926710975 cites W1773725721 @default.
- W2926710975 cites W1824873223 @default.
- W2926710975 cites W1862774878 @default.
- W2926710975 cites W1910848366 @default.
- W2926710975 cites W1965157206 @default.
- W2926710975 cites W1972006429 @default.
- W2926710975 cites W1972739246 @default.
- W2926710975 cites W1973874596 @default.
- W2926710975 cites W1976053959 @default.
- W2926710975 cites W1977373195 @default.
- W2926710975 cites W1980654946 @default.
- W2926710975 cites W1990992301 @default.
- W2926710975 cites W1991930901 @default.
- W2926710975 cites W1996583924 @default.
- W2926710975 cites W1996605319 @default.
- W2926710975 cites W1997114875 @default.
- W2926710975 cites W2003872705 @default.
- W2926710975 cites W2008650297 @default.
- W2926710975 cites W2009443452 @default.
- W2926710975 cites W2011910303 @default.
- W2926710975 cites W2014051729 @default.
- W2926710975 cites W2015784622 @default.
- W2926710975 cites W2025092145 @default.
- W2926710975 cites W2028861852 @default.
- W2926710975 cites W2030529885 @default.
- W2926710975 cites W2035789764 @default.
- W2926710975 cites W2046345187 @default.
- W2926710975 cites W2049106924 @default.
- W2926710975 cites W2053352622 @default.
- W2926710975 cites W2060997207 @default.
- W2926710975 cites W2066847273 @default.
- W2926710975 cites W2067585219 @default.
- W2926710975 cites W2071962829 @default.
- W2926710975 cites W2072362233 @default.
- W2926710975 cites W2080752012 @default.
- W2926710975 cites W2081019639 @default.
- W2926710975 cites W2081370753 @default.
- W2926710975 cites W2082732215 @default.
- W2926710975 cites W2084412222 @default.
- W2926710975 cites W2088651611 @default.
- W2926710975 cites W2097961915 @default.
- W2926710975 cites W2107554012 @default.
- W2926710975 cites W2108078777 @default.
- W2926710975 cites W2111214065 @default.
- W2926710975 cites W2122292170 @default.
- W2926710975 cites W2122683221 @default.
- W2926710975 cites W2133728642 @default.
- W2926710975 cites W2136503478 @default.
- W2926710975 cites W2136792826 @default.
- W2926710975 cites W2139204366 @default.
- W2926710975 cites W2140523553 @default.
- W2926710975 cites W2145189896 @default.
- W2926710975 cites W2150267627 @default.
- W2926710975 cites W2152239989 @default.
- W2926710975 cites W2154618092 @default.
- W2926710975 cites W2160655220 @default.
- W2926710975 cites W2162143298 @default.
- W2926710975 cites W2167251244 @default.
- W2926710975 cites W2170586414 @default.
- W2926710975 cites W2195777839 @default.
- W2926710975 cites W2216289728 @default.
- W2926710975 cites W2331098390 @default.
- W2926710975 cites W2338740599 @default.
- W2926710975 cites W2345498148 @default.
- W2926710975 cites W2345903844 @default.
- W2926710975 cites W2346744565 @default.
- W2926710975 cites W2517001432 @default.
- W2926710975 cites W2525154772 @default.
- W2926710975 cites W2529963495 @default.
- W2926710975 cites W2558818240 @default.
- W2926710975 cites W2562858475 @default.
- W2926710975 cites W2570390486 @default.
- W2926710975 cites W2576233835 @default.
- W2926710975 cites W2579076699 @default.
- W2926710975 cites W2587156779 @default.
- W2926710975 cites W2604621985 @default.
- W2926710975 cites W2738552159 @default.
- W2926710975 cites W2747163024 @default.
- W2926710975 cites W2749119966 @default.
- W2926710975 cites W2765568379 @default.
- W2926710975 cites W2767454473 @default.
- W2926710975 cites W2795720999 @default.
- W2926710975 cites W2804942066 @default.
- W2926710975 cites W2839967283 @default.
- W2926710975 cites W2886401819 @default.