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- W2926720872 abstract "Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed." @default.
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- W2926720872 date "2019-01-01" @default.
- W2926720872 modified "2023-10-11" @default.
- W2926720872 title "PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism" @default.
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- W2926720872 doi "https://doi.org/10.1007/978-3-030-12668-1_13" @default.
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