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- W2927060557 endingPage "231" @default.
- W2927060557 startingPage "191" @default.
- W2927060557 abstract "The biocomposites based on bioinert titanium VT1-0 (Ti) and Ti–40mass%Nb (Ti–40Nb) alloy with micro-arc calcium phosphate (CaP) biocoatings were developed. The physical and mechanical properties of Ti and Ti–40Nb are enhanced due to the formation of nanostructured and ultrafine-grained states by the severe plastic deformation method. The hydrophilic CaP coatings with rough relief, porous morphology, and high rate of bioresorption were formed by the micro-arc oxidation (MAO) method on Ti and Ti–40Nb. Biocomposites with enhanced antibacterial properties and biological activity were produced by addition into the CaP coating composition of Zn2+ and Cu2+ ions as well as wollastonite. The developed coatings independent of the metal substrate type not only had no toxic effect on the functional status in vitro of mesenchymal stromal cells culture but also apparently promoted to their osteogenic (according to alkaline phosphatase and osteocalcin secretion) activation. In this case, the Cu-incorporated CaP coatings and Zn-incorporated CaP coatings, to a greater extent, increased Jurkat T cell death two to three times by necrosis. It was presented the application examples of biocomposites based on nanostructured titanium with CaP coating in medical practice." @default.
- W2927060557 created "2019-04-11" @default.
- W2927060557 creator A5003867598 @default.
- W2927060557 creator A5022459627 @default.
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- W2927060557 creator A5077935089 @default.
- W2927060557 creator A5082048543 @default.
- W2927060557 creator A5091763630 @default.
- W2927060557 date "2019-04-05" @default.
- W2927060557 modified "2023-09-23" @default.
- W2927060557 title "Bioactive Micro‐arc Calcium Phosphate Coatings on Nanostructured and Ultrafine‐Grained Bioinert Metals and Alloys" @default.
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