FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2927233132> ?p ?o ?g. }

• W2927233132 endingPage "2403" @default.
• W2927233132 startingPage "2392" @default.
• W2927233132 abstract "Background MiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer. In this study, a ceRNA network was constructed, and new treatment and prognosis targets and biomarkers for breast cancer were explored. Methods A total of 1 096 cancer tissues and 112 adjacent normal tissues to cancer from the TCGA database were used to screen out significant differentially expressed mRNAs (DEMs), lncRNAs (DELs), and miRNAs (DEMis) to construct a ceRNA network. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to predict potential functions. Survival analysis was performed to predict which functions were significant for prognosis. Results From the analysis, 2 139 DEMs, 1 059 DELs, and 84 DEMis were obtained. Targeting predictions for DEMis-DELs and DEMis-DEMs can yield 26 DEMs, 90 DELs, and 18 DEMis. We performed GO enrichment analysis, and the results showed that the upregulated DEMs were involved in nucleosomes, extracellular regions, and nucleosome assembly, while the downregulated DEMs were mainly involved in Z disk, muscle contraction, and structural constituents of muscle. KEGG pathway analysis was performed on all DEMs, and the pathways were enriched in retinol metabolism, steroid hormone biosynthesis, and tyrosine metabolism. Through survival analysis of the ceRNA network, we identified four DEMs, two DELs, and two DEMis that were significant for poor prognosis. Conclusions This study suggested that constructing a ceRNA network and performing survival analysis on the network could screen out new significant treatment and prognosis targets and biomarkers." @default.
• W2927233132 created "2019-04-11" @default.
• W2927233132 creator A5010138509 @default.
• W2927233132 creator A5020991642 @default.
• W2927233132 creator A5024876931 @default.
• W2927233132 creator A5058363207 @default.
• W2927233132 creator A5073199916 @default.
• W2927233132 creator A5074460805 @default.
• W2927233132 creator A5079424962 @default.
• W2927233132 creator A5088575038 @default.
• W2927233132 date "2019-04-01" @default.
• W2927233132 modified "2023-10-18" @default.
• W2927233132 title "Identification of competitive endogenous RNAs network in breast cancer" @default.
• W2927233132 cites W1824682359 @default.
• W2927233132 cites W1890349608 @default.
• W2927233132 cites W1966498224 @default.
• W2927233132 cites W1996350041 @default.
• W2927233132 cites W2011458493 @default.
• W2927233132 cites W2046387002 @default.
• W2927233132 cites W2049331196 @default.
• W2927233132 cites W2055998706 @default.
• W2927233132 cites W2059073003 @default.
• W2927233132 cites W2091415346 @default.
• W2927233132 cites W2102767758 @default.
• W2927233132 cites W2130224358 @default.
• W2927233132 cites W2132893003 @default.
• W2927233132 cites W2160408484 @default.
• W2927233132 cites W2164804796 @default.
• W2927233132 cites W2272984102 @default.
• W2927233132 cites W2339719201 @default.
• W2927233132 cites W2342633832 @default.
• W2927233132 cites W2420947713 @default.
• W2927233132 cites W2547760434 @default.
• W2927233132 cites W2560322684 @default.
• W2927233132 cites W2573841129 @default.
• W2927233132 cites W2616188371 @default.
• W2927233132 cites W2774331997 @default.
• W2927233132 cites W2781525129 @default.
• W2927233132 cites W2793080946 @default.
• W2927233132 cites W2806678022 @default.
• W2927233132 cites W2810541292 @default.
• W2927233132 cites W2811121592 @default.
• W2927233132 cites W2820169417 @default.
• W2927233132 cites W2884129264 @default.
• W2927233132 doi "https://doi.org/10.1002/cam4.2099" @default.
• W2927233132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6536941" @default.
• W2927233132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30932362" @default.
• W2927233132 hasPublicationYear "2019" @default.
• W2927233132 type Work @default.
• W2927233132 sameAs 2927233132 @default.
• W2927233132 citedByCount "13" @default.
• W2927233132 countsByYear W29272331322020 @default.
• W2927233132 countsByYear W29272331322021 @default.
• W2927233132 countsByYear W29272331322022 @default.
• W2927233132 countsByYear W29272331322023 @default.
• W2927233132 crossrefType "journal-article" @default.
• W2927233132 hasAuthorship W2927233132A5010138509 @default.
• W2927233132 hasAuthorship W2927233132A5020991642 @default.
• W2927233132 hasAuthorship W2927233132A5024876931 @default.
• W2927233132 hasAuthorship W2927233132A5058363207 @default.
• W2927233132 hasAuthorship W2927233132A5073199916 @default.
• W2927233132 hasAuthorship W2927233132A5074460805 @default.
• W2927233132 hasAuthorship W2927233132A5079424962 @default.
• W2927233132 hasAuthorship W2927233132A5088575038 @default.
• W2927233132 hasBestOaLocation W29272331321 @default.
• W2927233132 hasConcept C104317684 @default.
• W2927233132 hasConcept C116834253 @default.
• W2927233132 hasConcept C121608353 @default.
• W2927233132 hasConcept C134018914 @default.
• W2927233132 hasConcept C145059251 @default.
• W2927233132 hasConcept C16613235 @default.
• W2927233132 hasConcept C530470458 @default.
• W2927233132 hasConcept C54355233 @default.
• W2927233132 hasConcept C59822182 @default.
• W2927233132 hasConcept C60365752 @default.
• W2927233132 hasConcept C62203573 @default.
• W2927233132 hasConcept C67705224 @default.
• W2927233132 hasConcept C70721500 @default.
• W2927233132 hasConcept C86803240 @default.
• W2927233132 hasConceptScore W2927233132C104317684 @default.
• W2927233132 hasConceptScore W2927233132C116834253 @default.
• W2927233132 hasConceptScore W2927233132C121608353 @default.
• W2927233132 hasConceptScore W2927233132C134018914 @default.
• W2927233132 hasConceptScore W2927233132C145059251 @default.
• W2927233132 hasConceptScore W2927233132C16613235 @default.
• W2927233132 hasConceptScore W2927233132C530470458 @default.
• W2927233132 hasConceptScore W2927233132C54355233 @default.
• W2927233132 hasConceptScore W2927233132C59822182 @default.
• W2927233132 hasConceptScore W2927233132C60365752 @default.
• W2927233132 hasConceptScore W2927233132C62203573 @default.
• W2927233132 hasConceptScore W2927233132C67705224 @default.
• W2927233132 hasConceptScore W2927233132C70721500 @default.
• W2927233132 hasConceptScore W2927233132C86803240 @default.
• W2927233132 hasIssue "5" @default.
• W2927233132 hasLocation W29272331321 @default.
• W2927233132 hasLocation W29272331322 @default.
• W2927233132 hasLocation W29272331323 @default.
• W2927233132 hasOpenAccess W2927233132 @default.

• next