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- W2927286860 abstract "Background: Acute kidney injury (AKI) complicating cardiogenic shock is associated with increased short-term mortality. We hypothesize that early HD or CRRT for AKI in patients with Impella-CP for cardiogenic shock improves survival. Methods: Retrospective chart-review identified 34 patients requiring Impella-CP for cardiogenic shock between January 2015 and December 2017. AKI was defined as increase in serum Cr >=0.3mg/dl or >=50% from baseline. Based on this definition, three groups were differentiated; no AKI, AKI without HD/CRRT and AKI+HD/CRRT. Pre-existing dialysis dependent patients were excluded. 30-day cardiovascular mortality (CV) was compared. Results: Of the 34 patients on Impella-CP for cardiogenic shock, 13 did not have AKI; 12 had AKI but did not receive HD/CRRT; and 9 received HD/CRRT for AKI. 30-day CV mortality was higher in the AKI without HD/CRRT group compared to no-AKI group [75% (9/12) vs 30.8% (4/13), p 0.03]. There was no significant difference in 30-day CV mortality of the AKI+HD/CRRT and no-AKI groups [22.2% (2/9) vs 30.8% (4/13), p 0.48]. In the 9 patients who received HD/CRRT, the indication was AKI not responding to diuretics. No other indications for HD were noted in all 34 patients. Hemoglobin >=11g/dl (p 0.008) and use of Calcium Channel Blockers (p 0.04) were associated with decreased incidence of AKI (Table 1). Mean serum creatinine was higher in the AKI+HD/CRRT than AKI without HD/CRRT group (p=0.01, Table 2). Conclusion: Despite the increased 30-day CV mortality associated with AKI in patients on Impella-CP for cardiogenic shock (p 0.03), there is no significant difference in 30-day CV mortality of patients who received HD/CRRT for AKI and those without AKI (p 0.48). Early initiation of HD/CRRT for AKI in patients on Impella-CP for cardiogenic shock may improve short-term CV mortality." @default.
- W2927286860 created "2019-04-11" @default.
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- W2927286860 date "2019-04-01" @default.
- W2927286860 modified "2023-09-25" @default.
- W2927286860 title "Abstract 199.1: Incidence and Outcomes of Acute Kidney Injury Requiring Renal Replacement Therapy in Patients on Percutaneous Mechanical Circulatory Support with Impella CP for Cardiogenic Shock; a Single Center Experience" @default.
- W2927286860 doi "https://doi.org/10.1161/hcq.12.suppl_1.199.1" @default.
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