Matches in SemOpenAlex for { <https://semopenalex.org/work/W2927287555> ?p ?o ?g. }
- W2927287555 abstract "Pluripotency emerges transiently during embryogenesis in two main forms with different developmental potential, termed naïve and primed states. Importantly, these pluripotent states can be recapitulated in vitro under specific culture conditions, representing a unique model to study the regulatory principles of development and cellular plasticity. Areas covered: A complex network of signaling pathways that senses intrinsic and extrinsic cues controls the fine balance between self-renewal and differentiation. Much of our knowledge on this tight regulation originates from epigenetic and transcriptomic approaches. However, the presence of post-transcriptional and post-translational mechanisms demands a direct assessment of the proteome in its multiple facets. Mass spectrometry-based proteomics is now a mature technique and has started to deliver new insights in the stem cell field. Expert opinion: Here, we review our current understanding on the mechanisms that dictate the spectrum of pluripotency levels. We put special emphasis on the emerging proteomic studies that focused on the molecular properties behind the naïve and primed states. In addition, we hypothesize on the impact that future developments in proteomic technologies can have to improve our view of pluripotency." @default.
- W2927287555 created "2019-04-11" @default.
- W2927287555 creator A5007084790 @default.
- W2927287555 creator A5040716806 @default.
- W2927287555 creator A5074693120 @default.
- W2927287555 date "2019-04-14" @default.
- W2927287555 modified "2023-10-18" @default.
- W2927287555 title "Proteotyping pluripotency with mass spectrometry" @default.
- W2927287555 cites W1521661677 @default.
- W2927287555 cites W1874303456 @default.
- W2927287555 cites W1964076580 @default.
- W2927287555 cites W1965754626 @default.
- W2927287555 cites W1972399884 @default.
- W2927287555 cites W1979273319 @default.
- W2927287555 cites W1984077980 @default.
- W2927287555 cites W1992160731 @default.
- W2927287555 cites W1992949513 @default.
- W2927287555 cites W1996310767 @default.
- W2927287555 cites W1998070636 @default.
- W2927287555 cites W2002511118 @default.
- W2927287555 cites W2008530548 @default.
- W2927287555 cites W2013295681 @default.
- W2927287555 cites W2014426141 @default.
- W2927287555 cites W2018765068 @default.
- W2927287555 cites W2018855387 @default.
- W2927287555 cites W2039432996 @default.
- W2927287555 cites W2058521801 @default.
- W2927287555 cites W2060608082 @default.
- W2927287555 cites W2063344286 @default.
- W2927287555 cites W2071141381 @default.
- W2927287555 cites W2074591015 @default.
- W2927287555 cites W2079244861 @default.
- W2927287555 cites W2081927805 @default.
- W2927287555 cites W2084699632 @default.
- W2927287555 cites W2086277161 @default.
- W2927287555 cites W2086328680 @default.
- W2927287555 cites W2090260381 @default.
- W2927287555 cites W2093822374 @default.
- W2927287555 cites W2096217402 @default.
- W2927287555 cites W2096391240 @default.
- W2927287555 cites W2101197781 @default.
- W2927287555 cites W2102345282 @default.
- W2927287555 cites W2105707485 @default.
- W2927287555 cites W2114526351 @default.
- W2927287555 cites W2115578546 @default.
- W2927287555 cites W2117895812 @default.
- W2927287555 cites W2118453371 @default.
- W2927287555 cites W2124348590 @default.
- W2927287555 cites W2124486107 @default.
- W2927287555 cites W2128551987 @default.
- W2927287555 cites W2138035159 @default.
- W2927287555 cites W2142482111 @default.
- W2927287555 cites W2152677707 @default.
- W2927287555 cites W2157458089 @default.
- W2927287555 cites W2158373820 @default.
- W2927287555 cites W2159046366 @default.
- W2927287555 cites W2159276924 @default.
- W2927287555 cites W2163679188 @default.
- W2927287555 cites W2167315449 @default.
- W2927287555 cites W2253271165 @default.
- W2927287555 cites W2256123818 @default.
- W2927287555 cites W2272852695 @default.
- W2927287555 cites W2288812985 @default.
- W2927287555 cites W2340761255 @default.
- W2927287555 cites W2399912172 @default.
- W2927287555 cites W2407888728 @default.
- W2927287555 cites W2507222891 @default.
- W2927287555 cites W2525191262 @default.
- W2927287555 cites W2539232660 @default.
- W2927287555 cites W2563522092 @default.
- W2927287555 cites W2602584217 @default.
- W2927287555 cites W2752405877 @default.
- W2927287555 cites W2765713566 @default.
- W2927287555 cites W2779468157 @default.
- W2927287555 cites W2791501381 @default.
- W2927287555 cites W2802342298 @default.
- W2927287555 cites W2803754954 @default.
- W2927287555 cites W2807862225 @default.
- W2927287555 cites W2810978970 @default.
- W2927287555 cites W2811227283 @default.
- W2927287555 cites W2889638147 @default.
- W2927287555 doi "https://doi.org/10.1080/14789450.2019.1604229" @default.
- W2927287555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30947573" @default.
- W2927287555 hasPublicationYear "2019" @default.
- W2927287555 type Work @default.
- W2927287555 sameAs 2927287555 @default.
- W2927287555 citedByCount "0" @default.
- W2927287555 crossrefType "journal-article" @default.
- W2927287555 hasAuthorship W2927287555A5007084790 @default.
- W2927287555 hasAuthorship W2927287555A5040716806 @default.
- W2927287555 hasAuthorship W2927287555A5074693120 @default.
- W2927287555 hasConcept C104317684 @default.
- W2927287555 hasConcept C104397665 @default.
- W2927287555 hasConcept C107459253 @default.
- W2927287555 hasConcept C145103041 @default.
- W2927287555 hasConcept C150194340 @default.
- W2927287555 hasConcept C162317418 @default.
- W2927287555 hasConcept C41091548 @default.
- W2927287555 hasConcept C46111723 @default.
- W2927287555 hasConcept C54355233 @default.