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• W2927340726 abstract "The main intent of this work (after the by chance finding, in archived histological slides) is to characterize one previously non‐described liver lesion of the Iberian barbel from the Vizela River (Portugal). This ran through a textile and dyeing industrial region. The lesion type was made of groups of foamy cells (presumptive macrophages), which appear either as a “smaller non‐nodular form,” without a connective tissue capsule and displaying an irregular profile, or as a “bigger nodular form,” presenting a thin capsule and a circular profile. The nodular forms could appear multi‐layered, resembling “cross‐sectioned onions”. The lesions number, dimension, and structural complexity were greater in bigger fish, appearing only after a history of poor water quality. In extreme cases, the lesions slightly protruded the liver surface. Special histological staining proved the connective tissue nature of the capsule (and its eventual septa), the presence of proteins, glycoproteins, lipofuscin, melanin, iron (putative hemosiderin), and copper, in a variable number of foamy cells within the lesions. At times, degenerating hepatocytes appeared at the border of the lesions. It is proposed that this lesion type incorporates both macrophages and degenerating hepatocytes, looking as one (unpublished) form of a macrophage aggregate. The term “foamy‐cell nodules” was advanced for this abnormality. The lesion could have been induced by pollution, because: no parasites were ever associated with the lesion; there was co‐existence of the lesion with a water quality status scored as “bad”; such lesion neither existed in fish sampled after mitigation and remediation measures nor in reference fish." @default.
• W2927340726 created "2019-04-11" @default.
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• W2927340726 date "2019-04-04" @default.
• W2927340726 modified "2023-10-16" @default.
• W2927340726 title "Uncommon hepatic macrophagic foamy‐cell nodules in Iberian barbel ( Lucio barbus bocagei Steindachner, 1864) from the Vizela River (Portugal)" @default.
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• W2927340726 doi "https://doi.org/10.1002/jemt.23260" @default.
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