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- W2927497573 abstract "The objectives of this study were to evaluate the anti-aging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (<1 kDa), and high molecular weight fractions (>1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (<20%) lower with all samples. Also, the digested FCHs and their >1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the >1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries." @default.
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- W2927497573 date "2019-03-31" @default.
- W2927497573 modified "2023-09-27" @default.
- W2927497573 title "Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation" @default.
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- W2927497573 doi "https://doi.org/10.3839/jabc.2019.015" @default.
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