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- W2927521772 endingPage "1397" @default.
- W2927521772 startingPage "1372" @default.
- W2927521772 abstract "An attractive approach to combat disease is to target theregulation of cell function. At the heart of this task are nuclear receptors (NRs); which control functions such as gene transcription. Arguably, the key player in this regulatory machinery is the retinoid X receptor (RXR). This NR associates with a third of the NRs found in humans. Scientists have hypothesized that controlling the activity of RXR is an attractive approach to control cellular functions that modulate diseases such as cancer, diabetes, Alzheimer's disease and Parkinson's disease. In this review, we will describe the key features of the RXR, present a historic perspective of the first RXR agonists, and discuss various templates that have been reported to activate RXR with a focus on their molecular structure, biological activity, and limitations. Finally, we will present an outlook of the field and future directions and considerations to synthesize or modulate RXR agonists to make these compounds a clinical reality." @default.
- W2927521772 created "2019-04-11" @default.
- W2927521772 creator A5014111838 @default.
- W2927521772 creator A5082244347 @default.
- W2927521772 date "2019-04-03" @default.
- W2927521772 modified "2023-10-04" @default.
- W2927521772 title "A review of the molecular design and biological activities of RXR agonists" @default.
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