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- W2927753063 endingPage "e1581528" @default.
- W2927753063 startingPage "e1581528" @default.
- W2927753063 abstract "Oncolytic viruses (OVs) preferentially target and kill cancer cells without affecting healthy cells through a multi-modal mechanism of action. While historically the direct killing activity of OVs was considered the primary mode of action, initiation or augmentation of a host antitumor immune response is now considered an essential aspect of oncolytic virotherapy. To improve oncolytic virotherapy, many studies focus on increasing virus replication and spread. In this article, we open for discussion the traditional dogma that correlates replication with the efficacy of OVs, pointing out several examples that oppose this principle." @default.
- W2927753063 created "2019-04-11" @default.
- W2927753063 creator A5055909975 @default.
- W2927753063 creator A5078849862 @default.
- W2927753063 date "2019-03-28" @default.
- W2927753063 modified "2023-10-15" @default.
- W2927753063 title "Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?" @default.
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- W2927753063 doi "https://doi.org/10.1080/2162402x.2019.1596006" @default.
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