Matches in SemOpenAlex for { <https://semopenalex.org/work/W2927754914> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2927754914 abstract "A simple and sensitive ultra-performance liquid chromatography tandem mass spectrometry method has been developed and validated for the analysis of cycloserine in patients' plasma. Using methanol, cyloserine and propranolol (internal standard (IS)) was extracted from plasma by protein precipitation procedure. The chromatographic separation was successfully achieved on Phenomenex KinetexTM PFP C18 (2.1 mm × 100 mm, 2.6 μm) reversed-phase column. Acidified with 0.1% formic acid, water and acetonitrile were used as mobile phases for gradient elution. Cycloserine and IS were detected by Xevo® TQ MS triple quadrupole tandem mass spectrometer. The transition of protonated precursor to product ion were monitored at 103 → 75 m/z and 260.2 → 183 m/z for cycloserine and IS, respectively. The lower limit of quantification was 0.01 μg/mL. The method was linear over the concentration range 0.01-50 μg/mL with average coefficient of determination of 0.9994. The within-run and between-run precision and accuracy were in the range 3.7-19.3% (RSD) and 98.7-117.3%, respectively. Processed cycloserine sample was stable for 48 hours at 8°C and after three freeze-thaw cycles. The extraction efficiency ranged between 88.7 and 91.2%. The method was successfully applied in a pharmacokinetic study for the determination of cycloserine in plasma of patients with drug-resistant tuberculosis." @default.
- W2927754914 created "2019-04-11" @default.
- W2927754914 creator A5045843488 @default.
- W2927754914 creator A5076614105 @default.
- W2927754914 date "2019-03-30" @default.
- W2927754914 modified "2023-10-18" @default.
- W2927754914 title "Sensitive Ultra-performance Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Cycloserine in Plasma for a Pharmacokinetics Study" @default.
- W2927754914 cites W2057620191 @default.
- W2927754914 cites W2072691242 @default.
- W2927754914 cites W2076078707 @default.
- W2927754914 cites W2080031358 @default.
- W2927754914 cites W2081639882 @default.
- W2927754914 cites W2111098948 @default.
- W2927754914 cites W2154552906 @default.
- W2927754914 cites W2460744562 @default.
- W2927754914 cites W2591170028 @default.
- W2927754914 cites W2605501381 @default.
- W2927754914 cites W2770544501 @default.
- W2927754914 doi "https://doi.org/10.1093/chromsci/bmz028" @default.
- W2927754914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30927010" @default.
- W2927754914 hasPublicationYear "2019" @default.
- W2927754914 type Work @default.
- W2927754914 sameAs 2927754914 @default.
- W2927754914 citedByCount "1" @default.
- W2927754914 countsByYear W29277549142019 @default.
- W2927754914 crossrefType "journal-article" @default.
- W2927754914 hasAuthorship W2927754914A5045843488 @default.
- W2927754914 hasAuthorship W2927754914A5076614105 @default.
- W2927754914 hasConcept C162356407 @default.
- W2927754914 hasConcept C172493649 @default.
- W2927754914 hasConcept C179998833 @default.
- W2927754914 hasConcept C185592680 @default.
- W2927754914 hasConcept C2777379063 @default.
- W2927754914 hasConcept C2781122200 @default.
- W2927754914 hasConcept C31827203 @default.
- W2927754914 hasConcept C43617362 @default.
- W2927754914 hasConcept C4725764 @default.
- W2927754914 hasConcept C501593827 @default.
- W2927754914 hasConcept C55493867 @default.
- W2927754914 hasConcept C64489805 @default.
- W2927754914 hasConcept C71043704 @default.
- W2927754914 hasConcept C73826308 @default.
- W2927754914 hasConcept C74774607 @default.
- W2927754914 hasConceptScore W2927754914C162356407 @default.
- W2927754914 hasConceptScore W2927754914C172493649 @default.
- W2927754914 hasConceptScore W2927754914C179998833 @default.
- W2927754914 hasConceptScore W2927754914C185592680 @default.
- W2927754914 hasConceptScore W2927754914C2777379063 @default.
- W2927754914 hasConceptScore W2927754914C2781122200 @default.
- W2927754914 hasConceptScore W2927754914C31827203 @default.
- W2927754914 hasConceptScore W2927754914C43617362 @default.
- W2927754914 hasConceptScore W2927754914C4725764 @default.
- W2927754914 hasConceptScore W2927754914C501593827 @default.
- W2927754914 hasConceptScore W2927754914C55493867 @default.
- W2927754914 hasConceptScore W2927754914C64489805 @default.
- W2927754914 hasConceptScore W2927754914C71043704 @default.
- W2927754914 hasConceptScore W2927754914C73826308 @default.
- W2927754914 hasConceptScore W2927754914C74774607 @default.
- W2927754914 hasLocation W29277549141 @default.
- W2927754914 hasLocation W29277549142 @default.
- W2927754914 hasOpenAccess W2927754914 @default.
- W2927754914 hasPrimaryLocation W29277549141 @default.
- W2927754914 hasRelatedWork W1497683841 @default.
- W2927754914 hasRelatedWork W1990978992 @default.
- W2927754914 hasRelatedWork W2004199349 @default.
- W2927754914 hasRelatedWork W2008934997 @default.
- W2927754914 hasRelatedWork W2027612788 @default.
- W2927754914 hasRelatedWork W2036451800 @default.
- W2927754914 hasRelatedWork W2064564571 @default.
- W2927754914 hasRelatedWork W2091497332 @default.
- W2927754914 hasRelatedWork W2094783222 @default.
- W2927754914 hasRelatedWork W2129757765 @default.
- W2927754914 isParatext "false" @default.
- W2927754914 isRetracted "false" @default.
- W2927754914 magId "2927754914" @default.
- W2927754914 workType "article" @default.