FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2927820693> ?p ?o ?g. }

• W2927820693 abstract "Abstract In people, colonization with Clostridium difficile , the leading cause of antibiotic-associated diarrhea, has been shown to be associated with distinct gut microbial features, including reduced bacterial community diversity and depletion of key taxa. In dogs, the gut microbiome features that define C. difficile colonization are less well understood. We sought to define the gut microbiome features associated with C. difficile colonization in puppies, a population where the prevalence of C. difficile has been shown to be elevated, and to define the effect of puppy age and litter upon these features and C. difficile risk. We collected fecal samples from weaned (n=27) and unweaned (n=74) puppies from 13 litters and analyzed the effects of colonization status, age and litter on microbial diversity using linear mixed effects models. Colonization with C. difficile was significantly associated with younger age, and colonized puppies had significantly decreased bacterial community diversity and differentially abundant taxa compared to non-colonized puppies, even when adjusting for age. C. difficile colonization remained associated with decreased bacterial community diversity, but the association did not reach statistical significance in a mixed effects model incorporating litter as a random effect. Even though litter explained a greater proportion (67%) of the variability in microbial diversity than colonization status, we nevertheless observed heterogeneity in gut microbial community diversity and colonization status within more than half of the litters, suggesting that the gut microbiome contributes to colonization resistance against C. difficile . The colonization of puppies with C. difficile has important implications for the potential zoonotic transfer of this organism to people. The identified associations point to mechanisms by which C. difficile colonization may be reduced." @default.
• W2927820693 created "2019-04-11" @default.
• W2927820693 creator A5013512599 @default.
• W2927820693 creator A5021195672 @default.
• W2927820693 creator A5023154420 @default.
• W2927820693 creator A5071658275 @default.
• W2927820693 creator A5074636830 @default.
• W2927820693 creator A5075213633 @default.
• W2927820693 creator A5090415813 @default.
• W2927820693 date "2019-04-04" @default.
• W2927820693 modified "2023-09-23" @default.
• W2927820693 title "Gut microbiome features associated withClostridium difficilecolonization in puppies" @default.
• W2927820693 cites W1779752944 @default.
• W2927820693 cites W1923292621 @default.
• W2927820693 cites W1987806279 @default.
• W2927820693 cites W2003543460 @default.
• W2927820693 cites W2004413279 @default.
• W2927820693 cites W2006278505 @default.
• W2927820693 cites W2008344135 @default.
• W2927820693 cites W2012464154 @default.
• W2927820693 cites W2018059663 @default.
• W2927820693 cites W2031611770 @default.
• W2927820693 cites W2034546710 @default.
• W2927820693 cites W2034730227 @default.
• W2927820693 cites W2053735591 @default.
• W2927820693 cites W2056279562 @default.
• W2927820693 cites W2061219514 @default.
• W2927820693 cites W2063536035 @default.
• W2927820693 cites W2066994233 @default.
• W2927820693 cites W2072970694 @default.
• W2927820693 cites W2074136150 @default.
• W2927820693 cites W2083231011 @default.
• W2927820693 cites W2100996093 @default.
• W2927820693 cites W2103376979 @default.
• W2927820693 cites W2104514647 @default.
• W2927820693 cites W2107440389 @default.
• W2927820693 cites W2121169789 @default.
• W2927820693 cites W2139607253 @default.
• W2927820693 cites W2147699265 @default.
• W2927820693 cites W2148425673 @default.
• W2927820693 cites W2152417392 @default.
• W2927820693 cites W2156646748 @default.
• W2927820693 cites W2158106947 @default.
• W2927820693 cites W2160378127 @default.
• W2927820693 cites W2163210794 @default.
• W2927820693 cites W2168249366 @default.
• W2927820693 cites W2174287538 @default.
• W2927820693 cites W2341427843 @default.
• W2927820693 cites W2385413224 @default.
• W2927820693 cites W2401404581 @default.
• W2927820693 cites W2607553436 @default.
• W2927820693 cites W2789348707 @default.
• W2927820693 cites W2791002863 @default.
• W2927820693 cites W2800234325 @default.
• W2927820693 cites W2840355095 @default.
• W2927820693 cites W2891593203 @default.
• W2927820693 cites W2892579011 @default.
• W2927820693 cites W2905108947 @default.
• W2927820693 cites W2915585851 @default.
• W2927820693 cites W2949073207 @default.
• W2927820693 cites W2997541776 @default.
• W2927820693 cites W4242289937 @default.
• W2927820693 doi "https://doi.org/10.1101/599647" @default.
• W2927820693 hasPublicationYear "2019" @default.
• W2927820693 type Work @default.
• W2927820693 sameAs 2927820693 @default.
• W2927820693 citedByCount "0" @default.
• W2927820693 crossrefType "posted-content" @default.
• W2927820693 hasAuthorship W2927820693A5013512599 @default.
• W2927820693 hasAuthorship W2927820693A5021195672 @default.
• W2927820693 hasAuthorship W2927820693A5023154420 @default.
• W2927820693 hasAuthorship W2927820693A5071658275 @default.
• W2927820693 hasAuthorship W2927820693A5074636830 @default.
• W2927820693 hasAuthorship W2927820693A5075213633 @default.
• W2927820693 hasAuthorship W2927820693A5090415813 @default.
• W2927820693 hasBestOaLocation W29278206931 @default.
• W2927820693 hasConcept C143121216 @default.
• W2927820693 hasConcept C18903297 @default.
• W2927820693 hasConcept C189506811 @default.
• W2927820693 hasConcept C2776927270 @default.
• W2927820693 hasConcept C2779429622 @default.
• W2927820693 hasConcept C2994496256 @default.
• W2927820693 hasConcept C501593827 @default.
• W2927820693 hasConcept C60644358 @default.
• W2927820693 hasConcept C61716771 @default.
• W2927820693 hasConcept C86803240 @default.
• W2927820693 hasConcept C89423630 @default.
• W2927820693 hasConcept C90856448 @default.
• W2927820693 hasConceptScore W2927820693C143121216 @default.
• W2927820693 hasConceptScore W2927820693C18903297 @default.
• W2927820693 hasConceptScore W2927820693C189506811 @default.
• W2927820693 hasConceptScore W2927820693C2776927270 @default.
• W2927820693 hasConceptScore W2927820693C2779429622 @default.
• W2927820693 hasConceptScore W2927820693C2994496256 @default.
• W2927820693 hasConceptScore W2927820693C501593827 @default.
• W2927820693 hasConceptScore W2927820693C60644358 @default.
• W2927820693 hasConceptScore W2927820693C61716771 @default.
• W2927820693 hasConceptScore W2927820693C86803240 @default.
• W2927820693 hasConceptScore W2927820693C89423630 @default.
• W2927820693 hasConceptScore W2927820693C90856448 @default.

• next