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• W2927896338 startingPage "e6700" @default.
• W2927896338 abstract "Ribonucleotide reductases (RNR) are essential enzymes for all known life forms. Their current taxonomic distribution suggests extensive horizontal gene transfer e.g., by processes involving viruses. To improve our understanding of the underlying processes, we characterized a monomeric class II RNR (NrdJm) enzyme from a Thermus virus, a subclass not present in any sequenced Thermus spp. genome. Phylogenetic analysis revealed a distant origin of the nrdJm gene with the most closely related sequences found in mesophiles or moderate thermophiles from the Firmicutes phylum. GC-content, codon usage and the ratio of coding to non-coding substitutions (dN/dS) suggest extensive adaptation of the gene in the virus in terms of nucleotide composition and amino acid sequence. The NrdJm enzyme is a monomeric B 12 -dependent RNR with nucleoside triphosphate specificity. It exhibits a temperature optimum at 60–70 °C, which is in the range of the growth optimum of Thermus spp. Experiments in combination with the Thermus thermophilus thioredoxin system show that the enzyme is able to retrieve electrons from the host NADPH pool via host thioredoxin and thioredoxin reductases. This is different from other characterized viral RNRs such as T4 phage RNR, where a viral thioredoxin is present. We hence show that the monomeric class II RNR, present in Thermus viruses, was likely transferred from an organism phylogenetically distant from the one they were isolated from, and adapted to the new host in genetic signature and amino acids sequence." @default.
• W2927896338 created "2019-04-11" @default.
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• W2927896338 date "2019-04-08" @default.
• W2927896338 modified "2023-10-10" @default.
• W2927896338 title "Non-host class II ribonucleotide reductase in Thermus viruses: sequence adaptation and host interaction" @default.
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• W2927896338 doi "https://doi.org/10.7717/peerj.6700" @default.
• W2927896338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459318" @default.
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• W2927896338 hasPublicationYear "2019" @default.
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