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- W2928025596 abstract "Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels in Asia to 2.3% in Spain, or an impressive 11.5% in Norway. The pathogenesis of psoriasis derives from complex genetic and environmental interactions, which creates aberrant crosstalk between keratinocytes and variated immune cell, resulting in open amplified inflammatory and pro-proliferative circuits. Both, innate and adaptive immune systems are known to be involved in the response at the cellular and humoral levels. Nevertheless, the exact molecular mechanisms are still under debate. Therefore, discovering useful therapeutic targets to stretch the molecular gaps in psoriasis pathogenesis and its associated comorbidities is still mandatory. So far, some mutagenic or pharmacological studies in vitro or using comparative vertebrate models have provided critical molecular insights and directed the human research. Although highly feasible in rodents, the versatile physiology, genetic similarity to humans and outstanding molecular toolbox available, suggest that elaborate forward genetic screenings are far easier to be conducted using the zebrafish model. Thus, in this review, we intend to briefly overview psoriasis and revise in a digested fashion the preclinical research models available, emphasizing the zebrafish as a powerful tool in the study of immune effectors on the same, and how it supports the discovering of new therapies that may help in controlling this widespread disease around the globe." @default.
- W2928025596 created "2019-04-11" @default.
- W2928025596 creator A5013323935 @default.
- W2928025596 creator A5020372336 @default.
- W2928025596 creator A5026121150 @default.
- W2928025596 creator A5027863333 @default.
- W2928025596 date "2019-08-01" @default.
- W2928025596 modified "2023-10-18" @default.
- W2928025596 title "Models of human psoriasis: Zebrafish the newly appointed player" @default.
- W2928025596 cites W1589480349 @default.
- W2928025596 cites W1870080799 @default.
- W2928025596 cites W1871057772 @default.
- W2928025596 cites W1898779455 @default.
- W2928025596 cites W1905701786 @default.
- W2928025596 cites W1967747842 @default.
- W2928025596 cites W1978606965 @default.
- W2928025596 cites W1979635026 @default.
- W2928025596 cites W1981239255 @default.
- W2928025596 cites W1984802220 @default.
- W2928025596 cites W1995984781 @default.
- W2928025596 cites W2004372679 @default.
- W2928025596 cites W2008086119 @default.
- W2928025596 cites W2015128080 @default.
- W2928025596 cites W2016325865 @default.
- W2928025596 cites W2021018799 @default.
- W2928025596 cites W2026046842 @default.
- W2928025596 cites W2026438690 @default.
- W2928025596 cites W2026967816 @default.
- W2928025596 cites W2029128580 @default.
- W2928025596 cites W2031335938 @default.
- W2928025596 cites W2034654881 @default.
- W2928025596 cites W2037332345 @default.
- W2928025596 cites W2040164730 @default.
- W2928025596 cites W2044887439 @default.
- W2928025596 cites W2050660850 @default.
- W2928025596 cites W2053489808 @default.
- W2928025596 cites W2056782822 @default.
- W2928025596 cites W2063512593 @default.
- W2928025596 cites W2063716214 @default.
- W2928025596 cites W2064512362 @default.
- W2928025596 cites W2064668416 @default.
- W2928025596 cites W2064709295 @default.
- W2928025596 cites W2065072232 @default.
- W2928025596 cites W2080323209 @default.
- W2928025596 cites W2083457899 @default.
- W2928025596 cites W2089102191 @default.
- W2928025596 cites W2090052656 @default.
- W2928025596 cites W2102441008 @default.
- W2928025596 cites W2103100739 @default.
- W2928025596 cites W2114074735 @default.
- W2928025596 cites W2120975662 @default.
- W2928025596 cites W2123342417 @default.
- W2928025596 cites W2124686679 @default.
- W2928025596 cites W2130098236 @default.
- W2928025596 cites W2136963255 @default.
- W2928025596 cites W2147510413 @default.
- W2928025596 cites W2149185484 @default.
- W2928025596 cites W2152904546 @default.
- W2928025596 cites W2164880184 @default.
- W2928025596 cites W2171157292 @default.
- W2928025596 cites W2179902402 @default.
- W2928025596 cites W2203549982 @default.
- W2928025596 cites W2327649147 @default.
- W2928025596 cites W2344070907 @default.
- W2928025596 cites W2412574361 @default.
- W2928025596 cites W2497470502 @default.
- W2928025596 cites W2513572057 @default.
- W2928025596 cites W2527564348 @default.
- W2928025596 cites W2555351070 @default.
- W2928025596 cites W2562021066 @default.
- W2928025596 cites W2588699638 @default.
- W2928025596 cites W2594840304 @default.
- W2928025596 cites W2601418567 @default.
- W2928025596 cites W2608454940 @default.
- W2928025596 cites W2707056792 @default.
- W2928025596 cites W2734398306 @default.
- W2928025596 cites W2736085689 @default.
- W2928025596 cites W2740051183 @default.
- W2928025596 cites W2761754244 @default.
- W2928025596 cites W2762592199 @default.
- W2928025596 cites W2765459340 @default.
- W2928025596 cites W2766862411 @default.
- W2928025596 cites W2769045700 @default.
- W2928025596 cites W2773298891 @default.
- W2928025596 cites W2774449624 @default.
- W2928025596 cites W2776484396 @default.
- W2928025596 cites W2778131634 @default.
- W2928025596 cites W2779184083 @default.
- W2928025596 cites W2779623922 @default.
- W2928025596 cites W2782274917 @default.
- W2928025596 cites W2787580274 @default.
- W2928025596 cites W2793144187 @default.
- W2928025596 cites W2793271483 @default.
- W2928025596 cites W2794902534 @default.
- W2928025596 cites W2801651752 @default.
- W2928025596 cites W2801736079 @default.
- W2928025596 cites W2806159238 @default.
- W2928025596 cites W2811171873 @default.