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• W2928053485 abstract "Purpose To assess the performance, in the presence of scanner instabilities, of three dynamic correction methods which integrate ∆ B 0 mapping into the chemical exchange saturation transfer (CEST) measurement and three established static ∆ B 0 ‐correction approaches. Methods A homogeneous phantom and five healthy volunteers were scanned with a CEST sequence at 7 T. The in vivo measurements were performed twice: first with unaltered system frequency and again applying frequency shifts during the CEST acquisition. In all cases, retrospective voxel‐wise ∆ B 0 ‐correction was performed using one intrinsic and two extrinsic [prescans with dual‐echo gradient‐echo and water saturation shift referencing (WASSR)] static approaches. These were compared with two intrinsic [using phase data directly generated by single‐echo or double‐echo GRE (gradient‐echo) CEST readout (CEST‐GRE‐2TE)] and one extrinsic [phase from interleaved dual‐echo EPI (echo planar imaging) navigator (NAV‐EPI‐2TE)] dynamic ∆ B 0 ‐correction approaches [allowing correction of each Z‐spectral point before magnetization transfer ratio asymmetry ( MTR asym ) analysis]. Results All three dynamic methods successfully mapped the induced drift. The intrinsic approaches were affected by the CEST labeling near water (∆ ω < |0.3| ppm). The MTR asym contrast was distorted by the frequency drift in the brain by up to 0.21%/Hz when static ∆ B 0 ‐corrections were applied, whereas the dynamic ∆ B 0 corrections reduced this to <0.01%/Hz without the need of external scans. The CEST‐GRE‐2TE and NAV‐EPI‐2TE resulted in highly consistent MTR asym values with/without drift for all subjects. Conclusion Reliable correction of scanner instabilities is essential to establish clinical CEST MRI. The three dynamic approaches presented improved the ∆ B 0 ‐correction performance significantly in the presence of frequency drift compared to established static methods. Among them, the self‐corrected CEST‐GRE‐2TE was the most accurate and straightforward to implement." @default.
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• W2928053485 date "2019-03-28" @default.
• W2928053485 modified "2023-10-16" @default.
• W2928053485 title "A comparison of static and dynamic ∆<i>B</i>₀ mapping methods for correction of CEST MRI in the presence of temporal <i>B</i>₀ field variations" @default.
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• W2928053485 doi "https://doi.org/10.1002/mrm.27750" @default.
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