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- W2928055732 abstract "Received TGP daily in highdoses of 1.2~1.8 g for 8wk, a significant improvement from baseline was noticed for not only clinical symptom but also 1 h erythrocyte sedimentation rate and serum rheumatoid factor titer. In addition, some immune dysfunction in RA patients, such as the higher levels of Interleukin-1(IL-1) producted by peripheral blood mononuclear cell(PBMC), the diminished PHA-induced proliferative responses and IL-2 production of lymphocytes, the depressed percentage of OKT8~(+) T cells in peripheral blood, and the elevated density of IL-2 receptor on lymphocytes, were recovered in state-dependent immunoregulation. Compared with low-dose methotrexate (MTX)(5~15 mg given weekly), the response with TGP occured earlier and milder than that with MTX, TGP was better tolerated and more safety than MTX. It indicated that TGP possess combined immunomodulatory and antiinflammatory activity, and hold promise as an important new therapeatic drug in RA. The result also indicated that IL-1 could be a simple and sensitive immunological marker for monitoring TGP effective and adjusting its doses." @default.
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- W2928055732 date "1994-01-01" @default.
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- W2928055732 title "Effect of total glucoside of Paeony on rheumatoid orthris patients" @default.
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