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• W2928316911 abstract "The Chinese forest musk deer (Moschus berezovskii; FMD) is an artiodactyl mammal and is both economically valuable and highly endangered. To investigate the genetic mechanisms of musk secretion and adaptive immunity in FMD, we compared its genome to nine other artiodactyl genomes. Comparative genomics demonstrated that eight positively selected genes (PSGs) in FMD were annotated in three KEGG pathways that were related to metabolic and synthetic activity of musk, similar to previous transcriptome studies. Functional enrichment analysis indicated that many PSGs were involved in the regulation of immune system processes, implying important reorganization of the immune system in FMD. FMD-specific missense mutations were found in two PSGs (MHC class II antigen DRA and ADA) that were classified as deleterious by PolyPhen-2, possibly contributing to immune adaptation to infectious diseases. Functional assessment showed that the FMD-specific mutation enhanced the ADA activity, which was likely to strengthen the immune defense against pathogenic invasion. Single nucleotide polymorphism-based inference showed the recent demographic trajectory for FMD. Our data and findings provide valuable genomic resources not only for studying the genetic mechanisms of musk secretion and adaptive immunity, but also for facilitating more effective management of the captive breeding programs for this endangered species." @default.
• W2928316911 created "2019-04-11" @default.
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• W2928316911 date "2019-03-23" @default.
• W2928316911 modified "2023-10-14" @default.
• W2928316911 title "Comparative Genomics Reveals the Genetic Mechanisms of Musk Secretion and Adaptive Immunity in Chinese Forest Musk Deer" @default.
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• W2928316911 doi "https://doi.org/10.1093/gbe/evz055" @default.
• W2928316911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450037" @default.
• W2928316911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30903183" @default.
• W2928316911 hasPublicationYear "2019" @default.
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