FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928424218> ?p ?o ?g. }

• W2928424218 abstract "Myelinoclastic diffuse sclerosis (MDS; also termed Schilder's disease) is a rare inflammatory demyelinating disorder of the central nervous system characterised by demyelination of vast areas of the white matter. It is unclear whether MDS is a variant of multiple sclerosis (MS) or a disease entity in its own right.To compare the cerebrospinal fluid (CSF) features of MDS with those of MS.Retrospective analysis of the CSF profile of all patients with MDS reported in the medical literature between 1960 and 2018.The most striking finding was a substantial lack of oligoclonal bands (OCBs) in MDS, which were absent in at least 77% (30/39) of all lumbar punctures (LP) in the total cohort and in 86% in the subgroup of patients with normal very long-chain fatty acid serum ratios (VLCFA). Almost all cases published in the past 15 years were negative for OCBs. These findings are in contrast to MS, in which OCBs are present in up to 98% of cases (p < 0.00001 when compared with reference works in MS; both in adult and in pediatric patients). CSF pleocytosis was absent in at least 79% (46/58) of all LP (p < 0.0001 vs. MS) and in 92% (24/26) of LPs in the VLCFA-tested subgroup. CSF total protein levels were elevated in 56% of all LPs (p < 0.0001 vs. MS) and in 63% of LPs in the VLCFA-tested subgroup and were often higher than in typical MS (> 100 mg/dL in 13/22; up to 220 mg/dL). EBV serum antibodies, which are present in virtually all patients with MS, and the so-called MRZ (measles/rubella/zoster) reaction, a highly specific marker of MS, were absent in all of the few patients tested. In addition, we discuss further differences between MS and MDS, taking into account also Schilder's original comprehensive case description from 1912.In the majority of patients diagnosed with MDS, CSF features differ significantly from those typically found in MS and are more similar to those previously reported in patients with myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-positive encephalomyelitis, aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders or Baló's concentric sclerosis. Our data suggest that MDS and MS are immunopathologically distinct entities in the majority of cases." @default.
• W2928424218 created "2019-04-11" @default.
• W2928424218 creator A5011686938 @default.
• W2928424218 creator A5056912783 @default.
• W2928424218 creator A5081462122 @default.
• W2928424218 creator A5089682223 @default.
• W2928424218 date "2019-02-28" @default.
• W2928424218 modified "2023-10-16" @default.
• W2928424218 title "Myelinoclastic diffuse sclerosis (Schilder’s disease) is immunologically distinct from multiple sclerosis: results from retrospective analysis of 92 lumbar punctures" @default.
• W2928424218 cites W109953008 @default.
• W2928424218 cites W1482033427 @default.
• W2928424218 cites W1539919386 @default.
• W2928424218 cites W1598350516 @default.
• W2928424218 cites W1878669653 @default.
• W2928424218 cites W1911607961 @default.
• W2928424218 cites W1966561815 @default.
• W2928424218 cites W1967464459 @default.
• W2928424218 cites W1970685254 @default.
• W2928424218 cites W1973335261 @default.
• W2928424218 cites W1980540422 @default.
• W2928424218 cites W1995267707 @default.
• W2928424218 cites W2004042304 @default.
• W2928424218 cites W2010054542 @default.
• W2928424218 cites W2011257132 @default.
• W2928424218 cites W2017271286 @default.
• W2928424218 cites W2021512471 @default.
• W2928424218 cites W2026488191 @default.
• W2928424218 cites W2026782390 @default.
• W2928424218 cites W2028669455 @default.
• W2928424218 cites W2032226755 @default.
• W2928424218 cites W2038941725 @default.
• W2928424218 cites W2042122734 @default.
• W2928424218 cites W2054597591 @default.
• W2928424218 cites W2054879522 @default.
• W2928424218 cites W2068599327 @default.
• W2928424218 cites W2071921946 @default.
• W2928424218 cites W2073267395 @default.
• W2928424218 cites W2075700417 @default.
• W2928424218 cites W2086080135 @default.
• W2928424218 cites W2110633552 @default.
• W2928424218 cites W2113948549 @default.
• W2928424218 cites W2114414511 @default.
• W2928424218 cites W2119588883 @default.
• W2928424218 cites W2122542523 @default.
• W2928424218 cites W2123794006 @default.
• W2928424218 cites W2124872079 @default.
• W2928424218 cites W2128597204 @default.
• W2928424218 cites W2129229339 @default.
• W2928424218 cites W2135292001 @default.
• W2928424218 cites W21354662 @default.
• W2928424218 cites W2137385534 @default.
• W2928424218 cites W2139113477 @default.
• W2928424218 cites W2141139602 @default.
• W2928424218 cites W2141462596 @default.
• W2928424218 cites W2143255467 @default.
• W2928424218 cites W2145118705 @default.
• W2928424218 cites W2146662840 @default.
• W2928424218 cites W2147062889 @default.
• W2928424218 cites W2148757073 @default.
• W2928424218 cites W2152156112 @default.
• W2928424218 cites W2152633379 @default.
• W2928424218 cites W2161037039 @default.
• W2928424218 cites W2164371036 @default.
• W2928424218 cites W2166066196 @default.
• W2928424218 cites W2171121768 @default.
• W2928424218 cites W2320436238 @default.
• W2928424218 cites W2333578592 @default.
• W2928424218 cites W2334985887 @default.
• W2928424218 cites W2528474010 @default.
• W2928424218 cites W2542372902 @default.
• W2928424218 cites W2545267953 @default.
• W2928424218 cites W2547149500 @default.
• W2928424218 cites W2548784535 @default.
• W2928424218 cites W2560923454 @default.
• W2928424218 cites W2561271023 @default.
• W2928424218 cites W2562970656 @default.
• W2928424218 cites W2598701066 @default.
• W2928424218 cites W2618637635 @default.
• W2928424218 cites W2663815898 @default.
• W2928424218 cites W2751480018 @default.
• W2928424218 cites W2760933032 @default.
• W2928424218 cites W2765280523 @default.
• W2928424218 cites W2777074421 @default.
• W2928424218 cites W2786802845 @default.
• W2928424218 cites W2796352461 @default.
• W2928424218 cites W2806973999 @default.
• W2928424218 cites W2890231352 @default.
• W2928424218 doi "https://doi.org/10.1186/s12974-019-1425-4" @default.
• W2928424218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6396538" @default.
• W2928424218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30819213" @default.
• W2928424218 hasPublicationYear "2019" @default.
• W2928424218 type Work @default.
• W2928424218 sameAs 2928424218 @default.
• W2928424218 citedByCount "15" @default.
• W2928424218 countsByYear W29284242182020 @default.
• W2928424218 countsByYear W29284242182021 @default.
• W2928424218 countsByYear W29284242182022 @default.
• W2928424218 crossrefType "journal-article" @default.
• W2928424218 hasAuthorship W2928424218A5011686938 @default.
• W2928424218 hasAuthorship W2928424218A5056912783 @default.

• next