Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928486537> ?p ?o ?g. }
- W2928486537 abstract "Objective: While Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD) patients compared to controls without neurodegenerative disease; we sought to evaluate longitudinal changes of this potential biomarker. Methods: SD-OCT retinal layer thicknesses were measured at baseline and after 1-2 years. Clinical criteria, genetic analysis, and a cerebrospinal fluid biomarker (total tau: beta-amyloid) to exclude likely underlying Alzheimer’s disease pathology were used to define a subgroup of predicted molecular pathology (i.e., tauopathy). Retinal layer thicknesses and rates of change in all FTD patients (n=16 patients, 30 eyes) and the tauopathy subgroup (n=9 patients,16 eyes) were compared to controls (n=30 controls, 47 eyes) using a generalized linear model accounting for inter-eye correlation and adjusting for age, sex, and race. Correlations between retinal layer thicknesses and Mini-Mental State Examinations (MMSE) were assessed. Results: Compared to controls, returning FTD patients (143 vs. 130 microns, p=0.005) and the tauopathy subgroup (143 vs. 128 microns, p=0.03) had thinner outer retinas but similar inner layer thicknesses. Compared to controls, the outer retina thinning rate was not significant for all FTD patients (p=0.34), but was significant for the tauopathy subgroup (-3.9 vs. 0.4 microns/year, p=0.03). Outer retina thickness change correlated with MMSE change in FTD patients (Spearman rho=0.60, p=0.02) and the tauopathy subgroup (rho=0.73, p=0.04). Conclusion: Our finding of FTD outer retina thinning persists and longitudinally correlates with disease progression. These findings were especially seen in probable tauopathy patients, which showed progressive outer retina thinning." @default.
- W2928486537 created "2019-04-11" @default.
- W2928486537 creator A5012724884 @default.
- W2928486537 creator A5014495173 @default.
- W2928486537 creator A5021597228 @default.
- W2928486537 creator A5033203504 @default.
- W2928486537 creator A5058317587 @default.
- W2928486537 creator A5075156212 @default.
- W2928486537 creator A5075827682 @default.
- W2928486537 creator A5075836236 @default.
- W2928486537 creator A5078133081 @default.
- W2928486537 creator A5081337965 @default.
- W2928486537 date "2019-04-04" @default.
- W2928486537 modified "2023-10-17" @default.
- W2928486537 title "Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration" @default.
- W2928486537 cites W1488074945 @default.
- W2928486537 cites W1796022698 @default.
- W2928486537 cites W1898743042 @default.
- W2928486537 cites W1983444691 @default.
- W2928486537 cites W1983648154 @default.
- W2928486537 cites W2008301592 @default.
- W2928486537 cites W2009534627 @default.
- W2928486537 cites W2016127754 @default.
- W2928486537 cites W2022671600 @default.
- W2928486537 cites W2026693637 @default.
- W2928486537 cites W2035999025 @default.
- W2928486537 cites W2047135904 @default.
- W2928486537 cites W2049917557 @default.
- W2928486537 cites W2062005421 @default.
- W2928486537 cites W2065840059 @default.
- W2928486537 cites W2073154799 @default.
- W2928486537 cites W2075584671 @default.
- W2928486537 cites W2094206043 @default.
- W2928486537 cites W2096578658 @default.
- W2928486537 cites W2097433680 @default.
- W2928486537 cites W2097621798 @default.
- W2928486537 cites W2100756624 @default.
- W2928486537 cites W2102286051 @default.
- W2928486537 cites W2106839031 @default.
- W2928486537 cites W2127318120 @default.
- W2928486537 cites W2128030851 @default.
- W2928486537 cites W2136557657 @default.
- W2928486537 cites W2138190873 @default.
- W2928486537 cites W2141349376 @default.
- W2928486537 cites W2141854336 @default.
- W2928486537 cites W2142720569 @default.
- W2928486537 cites W2149860264 @default.
- W2928486537 cites W2160266392 @default.
- W2928486537 cites W2164774194 @default.
- W2928486537 cites W2272796193 @default.
- W2928486537 cites W2281591380 @default.
- W2928486537 cites W2337889145 @default.
- W2928486537 cites W2396692072 @default.
- W2928486537 cites W2529175827 @default.
- W2928486537 cites W2574493514 @default.
- W2928486537 cites W2575483849 @default.
- W2928486537 cites W2582619151 @default.
- W2928486537 cites W2619097621 @default.
- W2928486537 cites W2623663856 @default.
- W2928486537 cites W2625796101 @default.
- W2928486537 cites W2743513645 @default.
- W2928486537 cites W2750510345 @default.
- W2928486537 cites W2751558556 @default.
- W2928486537 cites W2794239764 @default.
- W2928486537 cites W2807229912 @default.
- W2928486537 cites W2810823899 @default.
- W2928486537 cites W2886040290 @default.
- W2928486537 cites W942740964 @default.
- W2928486537 doi "https://doi.org/10.3389/fnins.2019.00298" @default.
- W2928486537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459211" @default.
- W2928486537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31019447" @default.
- W2928486537 hasPublicationYear "2019" @default.
- W2928486537 type Work @default.
- W2928486537 sameAs 2928486537 @default.
- W2928486537 citedByCount "13" @default.
- W2928486537 countsByYear W29284865372020 @default.
- W2928486537 countsByYear W29284865372021 @default.
- W2928486537 countsByYear W29284865372022 @default.
- W2928486537 countsByYear W29284865372023 @default.
- W2928486537 crossrefType "journal-article" @default.
- W2928486537 hasAuthorship W2928486537A5012724884 @default.
- W2928486537 hasAuthorship W2928486537A5014495173 @default.
- W2928486537 hasAuthorship W2928486537A5021597228 @default.
- W2928486537 hasAuthorship W2928486537A5033203504 @default.
- W2928486537 hasAuthorship W2928486537A5058317587 @default.
- W2928486537 hasAuthorship W2928486537A5075156212 @default.
- W2928486537 hasAuthorship W2928486537A5075827682 @default.
- W2928486537 hasAuthorship W2928486537A5075836236 @default.
- W2928486537 hasAuthorship W2928486537A5078133081 @default.
- W2928486537 hasAuthorship W2928486537A5081337965 @default.
- W2928486537 hasBestOaLocation W29284865371 @default.
- W2928486537 hasConcept C118487528 @default.
- W2928486537 hasConcept C126322002 @default.
- W2928486537 hasConcept C142724271 @default.
- W2928486537 hasConcept C143998085 @default.
- W2928486537 hasConcept C15744967 @default.
- W2928486537 hasConcept C164705383 @default.
- W2928486537 hasConcept C169760540 @default.
- W2928486537 hasConcept C2776925932 @default.
- W2928486537 hasConcept C2777093970 @default.