FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928560280> ?p ?o ?g. }

• W2928560280 abstract "Abstract PIF1 family helicases represent a highly conserved class of enzymes involved in multiple aspects of genome maintenance. Many PIF1 helicase are multi-domain proteins, but the functions of their non-helicase domains are poorly understood. Here, we characterized how the N-terminal domain (NTD) of the Saccharomyces cerevisiae Pif1 helicase affects its functions both in vivo and in vitro . Removal of the Pif1 NTD alleviated the toxicity associated with Pif1 over-expression in yeast. Biochemically, the N-terminally truncated Pif1 (Pif1ΔN) retained in vitro DNA binding, DNA unwinding, and telomerase regulation activities, but these activities differed markedly from those displayed by full-length recombinant Pif1. However, Pif1ΔN was still able to synergize with the Hrq1 helicase to inhibit telomerase activity in vitro , similar to full-length Pif1. These data impact our understanding of PIF1 helicase evolution and the roles of these enzymes in the maintenance of genome integrity." @default.
• W2928560280 created "2019-04-11" @default.
• W2928560280 creator A5015593712 @default.
• W2928560280 creator A5028783197 @default.
• W2928560280 creator A5061031479 @default.
• W2928560280 date "2019-04-02" @default.
• W2928560280 modified "2023-09-28" @default.
• W2928560280 title "The biochemical activities of the Saccharomyces cerevisiae Pif1 helicase are regulated by its N-terminal domain" @default.
• W2928560280 cites W105499662 @default.
• W2928560280 cites W1538603370 @default.
• W2928560280 cites W1966744160 @default.
• W2928560280 cites W1973535211 @default.
• W2928560280 cites W1988625619 @default.
• W2928560280 cites W2004099247 @default.
• W2928560280 cites W2006220727 @default.
• W2928560280 cites W2011718165 @default.
• W2928560280 cites W2052740988 @default.
• W2928560280 cites W2060059417 @default.
• W2928560280 cites W2070647550 @default.
• W2928560280 cites W2075665556 @default.
• W2928560280 cites W2078144482 @default.
• W2928560280 cites W2090782725 @default.
• W2928560280 cites W2096160674 @default.
• W2928560280 cites W2098609152 @default.
• W2928560280 cites W2098933663 @default.
• W2928560280 cites W2110880183 @default.
• W2928560280 cites W2120403234 @default.
• W2928560280 cites W2127392515 @default.
• W2928560280 cites W2135087774 @default.
• W2928560280 cites W2147344322 @default.
• W2928560280 cites W2162261435 @default.
• W2928560280 cites W2162980545 @default.
• W2928560280 cites W2163546813 @default.
• W2928560280 cites W2165786451 @default.
• W2928560280 cites W2226186365 @default.
• W2928560280 cites W2590204906 @default.
• W2928560280 cites W2604513357 @default.
• W2928560280 cites W2787484265 @default.
• W2928560280 cites W2792165653 @default.
• W2928560280 cites W2887829978 @default.
• W2928560280 doi "https://doi.org/10.1101/596098" @default.
• W2928560280 hasPublicationYear "2019" @default.
• W2928560280 type Work @default.
• W2928560280 sameAs 2928560280 @default.
• W2928560280 citedByCount "2" @default.
• W2928560280 countsByYear W29285602802020 @default.
• W2928560280 crossrefType "posted-content" @default.
• W2928560280 hasAuthorship W2928560280A5015593712 @default.
• W2928560280 hasAuthorship W2928560280A5028783197 @default.
• W2928560280 hasAuthorship W2928560280A5061031479 @default.
• W2928560280 hasBestOaLocation W29285602801 @default.
• W2928560280 hasConcept C104317684 @default.
• W2928560280 hasConcept C141231307 @default.
• W2928560280 hasConcept C153911025 @default.
• W2928560280 hasConcept C161223559 @default.
• W2928560280 hasConcept C177336024 @default.
• W2928560280 hasConcept C2777576037 @default.
• W2928560280 hasConcept C2779222958 @default.
• W2928560280 hasConcept C40767141 @default.
• W2928560280 hasConcept C552990157 @default.
• W2928560280 hasConcept C55493867 @default.
• W2928560280 hasConcept C67705224 @default.
• W2928560280 hasConcept C86803240 @default.
• W2928560280 hasConcept C94581717 @default.
• W2928560280 hasConcept C95444343 @default.
• W2928560280 hasConceptScore W2928560280C104317684 @default.
• W2928560280 hasConceptScore W2928560280C141231307 @default.
• W2928560280 hasConceptScore W2928560280C153911025 @default.
• W2928560280 hasConceptScore W2928560280C161223559 @default.
• W2928560280 hasConceptScore W2928560280C177336024 @default.
• W2928560280 hasConceptScore W2928560280C2777576037 @default.
• W2928560280 hasConceptScore W2928560280C2779222958 @default.
• W2928560280 hasConceptScore W2928560280C40767141 @default.
• W2928560280 hasConceptScore W2928560280C552990157 @default.
• W2928560280 hasConceptScore W2928560280C55493867 @default.
• W2928560280 hasConceptScore W2928560280C67705224 @default.
• W2928560280 hasConceptScore W2928560280C86803240 @default.
• W2928560280 hasConceptScore W2928560280C94581717 @default.
• W2928560280 hasConceptScore W2928560280C95444343 @default.
• W2928560280 hasLocation W29285602801 @default.
• W2928560280 hasLocation W29285602802 @default.
• W2928560280 hasOpenAccess W2928560280 @default.
• W2928560280 hasPrimaryLocation W29285602801 @default.
• W2928560280 hasRelatedWork W1988780940 @default.
• W2928560280 hasRelatedWork W1991754576 @default.
• W2928560280 hasRelatedWork W2048897962 @default.
• W2928560280 hasRelatedWork W2051397501 @default.
• W2928560280 hasRelatedWork W2134726249 @default.
• W2928560280 hasRelatedWork W2473842640 @default.
• W2928560280 hasRelatedWork W2568162672 @default.
• W2928560280 hasRelatedWork W2589553298 @default.
• W2928560280 hasRelatedWork W2754763401 @default.
• W2928560280 hasRelatedWork W2766363340 @default.
• W2928560280 hasRelatedWork W2883755935 @default.
• W2928560280 hasRelatedWork W2941726660 @default.
• W2928560280 hasRelatedWork W2949805591 @default.
• W2928560280 hasRelatedWork W2952167957 @default.
• W2928560280 hasRelatedWork W3100927414 @default.
• W2928560280 hasRelatedWork W3143544714 @default.
• W2928560280 hasRelatedWork W3148029737 @default.

• next