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- W2928565511 abstract "Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G0) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, global protein levels need to be precisely doubled at each cell division in order to maintain cellular homeostasis, but we still lack a quantitative understanding of how this is achieved. Recent studies have shed light on cell cycle-dependent changes in protein synthesis and degradation rates. Here we discuss current population-based and single cell approaches used to assess protein synthesis and degradation, and review the insights they have provided into the dynamics of protein turnover in different cell cycle phases." @default.
- W2928565511 created "2019-04-11" @default.
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- W2928565511 date "2019-03-30" @default.
- W2928565511 modified "2023-10-12" @default.
- W2928565511 title "Dynamics of protein synthesis and degradation through the cell cycle" @default.
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- W2928565511 doi "https://doi.org/10.1080/15384101.2019.1598725" @default.
- W2928565511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6527273" @default.
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