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• W2928590943 abstract "European lung cancer screening studies using computed tomography (CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time (VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol (Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT (a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.The diagnostic performance of volume- and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations." @default.
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• W2928590943 date "2019-01-01" @default.
• W2928590943 modified "2023-09-25" @default.
• W2928590943 title "Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study" @default.
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• W2928590943 doi "https://doi.org/10.20892/j.issn.2095-3941.2018.0237" @default.
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