Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928705429> ?p ?o ?g. }
- W2928705429 endingPage "178" @default.
- W2928705429 startingPage "157" @default.
- W2928705429 abstract "Non-viral gene delivery to skeletal muscle was one of the first applications of gene therapy that went into the clinic, mainly because skeletal muscle is an easily accessible tissue for local gene transfer and non-viral vectors have a relatively safe and low immunogenic track record. However, plasmid DNA, naked or complexed to the various chemistries, turn out to be moderately efficient in humans when injected locally and very inefficient (and very toxic in some cases) when injected systemically. A number of clinical applications have been initiated however, based on transgenes that were adapted to good local impact and/or to a wide physiological outcome (i.e., strong humoral and cellular immune responses following the introduction of DNA vaccines). Neuromuscular diseases seem more challenging for non-viral vectors. Nevertheless, the local production of therapeutic proteins that may act distantly from the injected site and/or the hydrodynamic perfusion of safe plasmids remains a viable basis for the non-viral gene therapy of muscle disorders, cachexia, as well as peripheral neuropathies." @default.
- W2928705429 created "2019-04-11" @default.
- W2928705429 creator A5002346621 @default.
- W2928705429 date "2019-01-01" @default.
- W2928705429 modified "2023-09-23" @default.
- W2928705429 title "Non-viral Vector for Muscle-Mediated Gene Therapy" @default.
- W2928705429 cites W140736463 @default.
- W2928705429 cites W1485698350 @default.
- W2928705429 cites W1556818178 @default.
- W2928705429 cites W1557603671 @default.
- W2928705429 cites W1573089278 @default.
- W2928705429 cites W1576238436 @default.
- W2928705429 cites W1609543516 @default.
- W2928705429 cites W1688526230 @default.
- W2928705429 cites W1727428687 @default.
- W2928705429 cites W1964552840 @default.
- W2928705429 cites W1966327374 @default.
- W2928705429 cites W1967109108 @default.
- W2928705429 cites W1969918693 @default.
- W2928705429 cites W1970267929 @default.
- W2928705429 cites W1970510706 @default.
- W2928705429 cites W1971290197 @default.
- W2928705429 cites W1973911001 @default.
- W2928705429 cites W1974465041 @default.
- W2928705429 cites W1974661973 @default.
- W2928705429 cites W1975747252 @default.
- W2928705429 cites W1976139716 @default.
- W2928705429 cites W1978584491 @default.
- W2928705429 cites W1979273971 @default.
- W2928705429 cites W1983360225 @default.
- W2928705429 cites W1989439562 @default.
- W2928705429 cites W1989509928 @default.
- W2928705429 cites W1990804768 @default.
- W2928705429 cites W1993033761 @default.
- W2928705429 cites W1993040033 @default.
- W2928705429 cites W1993264880 @default.
- W2928705429 cites W1996211384 @default.
- W2928705429 cites W1998371600 @default.
- W2928705429 cites W1999625461 @default.
- W2928705429 cites W2000806258 @default.
- W2928705429 cites W2003721378 @default.
- W2928705429 cites W2003904826 @default.
- W2928705429 cites W2005050639 @default.
- W2928705429 cites W2007098121 @default.
- W2928705429 cites W2008759079 @default.
- W2928705429 cites W2010655741 @default.
- W2928705429 cites W2010740805 @default.
- W2928705429 cites W2011406504 @default.
- W2928705429 cites W2013905916 @default.
- W2928705429 cites W2014495927 @default.
- W2928705429 cites W2014825046 @default.
- W2928705429 cites W2014976983 @default.
- W2928705429 cites W2015789556 @default.
- W2928705429 cites W2016110802 @default.
- W2928705429 cites W2016151951 @default.
- W2928705429 cites W2017955222 @default.
- W2928705429 cites W2018116983 @default.
- W2928705429 cites W2019142417 @default.
- W2928705429 cites W2020026758 @default.
- W2928705429 cites W2022158202 @default.
- W2928705429 cites W2022434236 @default.
- W2928705429 cites W2024451640 @default.
- W2928705429 cites W2026328850 @default.
- W2928705429 cites W2026580009 @default.
- W2928705429 cites W2028603322 @default.
- W2928705429 cites W2029591487 @default.
- W2928705429 cites W2030008253 @default.
- W2928705429 cites W2030239024 @default.
- W2928705429 cites W2033034221 @default.
- W2928705429 cites W2036212880 @default.
- W2928705429 cites W2036728549 @default.
- W2928705429 cites W2042140512 @default.
- W2928705429 cites W2043100917 @default.
- W2928705429 cites W2045178852 @default.
- W2928705429 cites W2045715816 @default.
- W2928705429 cites W2045787527 @default.
- W2928705429 cites W2047207622 @default.
- W2928705429 cites W2055696568 @default.
- W2928705429 cites W2057123011 @default.
- W2928705429 cites W2057587268 @default.
- W2928705429 cites W2061394006 @default.
- W2928705429 cites W2064605119 @default.
- W2928705429 cites W2067072940 @default.
- W2928705429 cites W2070838346 @default.
- W2928705429 cites W2073598353 @default.
- W2928705429 cites W2075323420 @default.
- W2928705429 cites W2078066176 @default.
- W2928705429 cites W2078966715 @default.
- W2928705429 cites W2083008217 @default.
- W2928705429 cites W2085357369 @default.
- W2928705429 cites W2086274688 @default.
- W2928705429 cites W2087916955 @default.
- W2928705429 cites W2088178092 @default.
- W2928705429 cites W2095475784 @default.
- W2928705429 cites W2098902079 @default.
- W2928705429 cites W2103202831 @default.
- W2928705429 cites W2105323221 @default.
- W2928705429 cites W2105413362 @default.