Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928735992> ?p ?o ?g. }
- W2928735992 abstract "Sound information is transduced into graded receptor potential by cochlear hair cells and encoded as discrete action potentials of auditory nerve fibers. In the cochlear nucleus, auditory nerve fibers convey this information through morphologically distinct synaptic terminals onto bushy (BCs) and stellate cells (SCs) for processing of different sound features. With expanding use of transgenic mouse models, it is increasingly important to understand the in vivo functional development of these neurons in mice. We characterized the maturation of spontaneous and acoustically evoked activity in BCs and SCs by acquiring single-unit juxtacellular recordings between hearing onset (P12) and young adulthood (P30) of anesthetized CBA/J mice. In both cell types, hearing sensitivity and characteristic frequency range are mostly adult-like by P14, consistent with rapid maturation of the auditory periphery. In BCs, however, some physiological features like maximal firing rate, dynamic range, temporal response properties, recovery from post-stimulus depression, first spike latency and encoding of sinusoid amplitude modulation undergo further maturation up to P18. In SCs, the development of excitatory responses is even more prolonged, indicated by a gradual increase in spontaneous and maximum firing rates up to P30. In the same cell type, broadly tuned acoustically evoked inhibition is immediately effective at hearing onset, covering the low- and high-frequency flanks of the excitatory response area. Together, these data suggest that maturation of auditory processing in the parallel ascending BC and SC streams engages distinct mechanisms at the first central synapses that may differently depend on the early auditory experience." @default.
- W2928735992 created "2019-04-11" @default.
- W2928735992 creator A5014330416 @default.
- W2928735992 creator A5017535023 @default.
- W2928735992 creator A5034415348 @default.
- W2928735992 creator A5043222005 @default.
- W2928735992 creator A5061891485 @default.
- W2928735992 creator A5077600948 @default.
- W2928735992 date "2019-03-28" @default.
- W2928735992 modified "2023-10-04" @default.
- W2928735992 title "Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset" @default.
- W2928735992 cites W1207326001 @default.
- W2928735992 cites W1265050709 @default.
- W2928735992 cites W1273263022 @default.
- W2928735992 cites W135189209 @default.
- W2928735992 cites W1479792666 @default.
- W2928735992 cites W1479804274 @default.
- W2928735992 cites W1484837231 @default.
- W2928735992 cites W1487102420 @default.
- W2928735992 cites W1487825872 @default.
- W2928735992 cites W1510343038 @default.
- W2928735992 cites W1515323557 @default.
- W2928735992 cites W1561818412 @default.
- W2928735992 cites W1577757039 @default.
- W2928735992 cites W1607957700 @default.
- W2928735992 cites W1778293074 @default.
- W2928735992 cites W1815650112 @default.
- W2928735992 cites W1858333280 @default.
- W2928735992 cites W1877594537 @default.
- W2928735992 cites W1889995503 @default.
- W2928735992 cites W1919554660 @default.
- W2928735992 cites W1921705234 @default.
- W2928735992 cites W1936597859 @default.
- W2928735992 cites W1957242737 @default.
- W2928735992 cites W1959457034 @default.
- W2928735992 cites W1967265457 @default.
- W2928735992 cites W1968467597 @default.
- W2928735992 cites W1971194886 @default.
- W2928735992 cites W1971400889 @default.
- W2928735992 cites W1971428710 @default.
- W2928735992 cites W1972168487 @default.
- W2928735992 cites W1974005265 @default.
- W2928735992 cites W1974134481 @default.
- W2928735992 cites W1974932989 @default.
- W2928735992 cites W1975998934 @default.
- W2928735992 cites W1976113189 @default.
- W2928735992 cites W1976380310 @default.
- W2928735992 cites W1977565730 @default.
- W2928735992 cites W1978159855 @default.
- W2928735992 cites W1978923377 @default.
- W2928735992 cites W1979620981 @default.
- W2928735992 cites W1980243386 @default.
- W2928735992 cites W1980437822 @default.
- W2928735992 cites W1983446514 @default.
- W2928735992 cites W1984209465 @default.
- W2928735992 cites W1986329747 @default.
- W2928735992 cites W1987971958 @default.
- W2928735992 cites W1990133763 @default.
- W2928735992 cites W1992890284 @default.
- W2928735992 cites W1993339644 @default.
- W2928735992 cites W1993463851 @default.
- W2928735992 cites W1993689596 @default.
- W2928735992 cites W1993853432 @default.
- W2928735992 cites W1996481744 @default.
- W2928735992 cites W2002602712 @default.
- W2928735992 cites W2002715951 @default.
- W2928735992 cites W2005146186 @default.
- W2928735992 cites W2007993421 @default.
- W2928735992 cites W2008142532 @default.
- W2928735992 cites W2008579029 @default.
- W2928735992 cites W2009317697 @default.
- W2928735992 cites W2010482736 @default.
- W2928735992 cites W2011420265 @default.
- W2928735992 cites W2011941207 @default.
- W2928735992 cites W2013352517 @default.
- W2928735992 cites W2013667500 @default.
- W2928735992 cites W2015103469 @default.
- W2928735992 cites W2015544947 @default.
- W2928735992 cites W2016122143 @default.
- W2928735992 cites W2018927169 @default.
- W2928735992 cites W2019747051 @default.
- W2928735992 cites W2024816019 @default.
- W2928735992 cites W2026763791 @default.
- W2928735992 cites W2028789389 @default.
- W2928735992 cites W2030428080 @default.
- W2928735992 cites W2030597739 @default.
- W2928735992 cites W2033866160 @default.
- W2928735992 cites W2035182425 @default.
- W2928735992 cites W2036515774 @default.
- W2928735992 cites W2036732690 @default.
- W2928735992 cites W2037618838 @default.
- W2928735992 cites W2038560660 @default.
- W2928735992 cites W2038794139 @default.
- W2928735992 cites W2038913258 @default.
- W2928735992 cites W2039664217 @default.
- W2928735992 cites W2041077974 @default.
- W2928735992 cites W2041580402 @default.
- W2928735992 cites W2042747699 @default.
- W2928735992 cites W2045089906 @default.
- W2928735992 cites W2045206593 @default.