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- W2928760861 abstract "The article presents literature data of the possible role of vitamin D (VD) and polymorphism of the gene of the vitamin D receptors (VDR) in the pathogenetic mechanisms of the formation of pregnancy complications associated with intrauterine infection. Information of the modern approach to the importance of the vitamin D / VD receptor system in the regulation of physiological processes associated with the presence of VD receptors in many organs and tissues is presented. Particular attention to the presence of calcitriol receptors directly in the organs of the reproductive system is paid, the action of which is realized in a genomic and non-genomic way.Information about participation of vitamin D in the regulation of the balance between specific and nonspecific immunity during pregnancy, on the regulation and proliferation of immunocompetent cells, on the presence of mitochondrial enzyme 1a-hydroxylase (CYP27B1) directly in the trophoblast and the placenta, where the extra-renal synthesis of the active metabolite VD is underlined. It is shown that calcitriol can regulate the synthesis of antimicrobial peptides, which play a key role in the innate immune response, and an increase calcitriol in the inflammatory focus as a protective reaction is considered. The main effect of calcitriol on the immune system is to simulate T-cell immunity.Data on possible mechanisms for regulating the activity of a cytokines with pro- and anti-inflammatory effects in the presence of calcitriol are presented. In the trophoblast under the influence of calcitriol phagocytosis and chemotaxis of macrophages are enhanced, by the following activation of the cathelicidin peptide with antimicrobial action, and the negative effect of proinflammatory cytokines is reduced. Separately, the problem of the immune adaptation of the pregnant woman’s under the vitamin D deficiency status and polymorphism of genes encoding VDR is presented. It is assumed that under the VD-deficiency status, the probability of the intrauterine infection really increases: further research to refine the assumptions is needed." @default.
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- W2928760861 date "2019-03-29" @default.
- W2928760861 modified "2023-10-18" @default.
- W2928760861 title "Calcitriol and polymorphism of the gene of the receptor vitamin D in the pathogenesis of perinatal infection (review)" @default.
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- W2928760861 doi "https://doi.org/10.24061/2413-4260.ix.1.31.2019.12" @default.
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