Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928770856> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2928770856 abstract "Abstract Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown to have promising results in a pilot study with patients suffering from Alzheimer’s disease (AD). A recent study in aged monkeys shows a novel intermittent stimulation pattern to have superior cognitive benefits over continuous paradigms. Objective/Hypothesis We aimed at comparing the cognitive effects elicited by intermittent and continuous NBM stimulation paradigms in an animal model for AD (TgF344-AD rat line; TG), i.e. rats expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD. Methods In this exploratory study, aged APP/PS1 rats were tested pre-, and post implantation with several stimulation parameters, i.e. unilateral- or bilateral-intermittent, and bilateral-continuous, while performing various behavioral tasks (open field, novel object recognition, and modified Barnes maze). Results and Conclusion Bilateral-intermittent NBM DBS allowed aged TG rats to perform better and maintain their performance longer in a spatial memory task, as compared to other conditions. These data support the notion that NBM DBS could be further refined in the clinic, thereby improving patient care." @default.
- W2928770856 created "2019-04-11" @default.
- W2928770856 creator A5005468329 @default.
- W2928770856 creator A5031114539 @default.
- W2928770856 creator A5037171783 @default.
- W2928770856 creator A5057109503 @default.
- W2928770856 date "2019-04-05" @default.
- W2928770856 modified "2023-09-26" @default.
- W2928770856 title "Cognitive Improvements after Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s disease; a Preliminary Approach" @default.
- W2928770856 cites W1820013501 @default.
- W2928770856 cites W2015892563 @default.
- W2928770856 cites W2018141662 @default.
- W2928770856 cites W2090150925 @default.
- W2928770856 cites W2113460545 @default.
- W2928770856 cites W2140343650 @default.
- W2928770856 cites W2166578434 @default.
- W2928770856 cites W2492515927 @default.
- W2928770856 cites W2582295304 @default.
- W2928770856 cites W2729118560 @default.
- W2928770856 cites W2762467677 @default.
- W2928770856 cites W2767097370 @default.
- W2928770856 cites W2801687739 @default.
- W2928770856 cites W2889539445 @default.
- W2928770856 doi "https://doi.org/10.1101/600296" @default.
- W2928770856 hasPublicationYear "2019" @default.
- W2928770856 type Work @default.
- W2928770856 sameAs 2928770856 @default.
- W2928770856 citedByCount "0" @default.
- W2928770856 crossrefType "posted-content" @default.
- W2928770856 hasAuthorship W2928770856A5005468329 @default.
- W2928770856 hasAuthorship W2928770856A5031114539 @default.
- W2928770856 hasAuthorship W2928770856A5037171783 @default.
- W2928770856 hasAuthorship W2928770856A5057109503 @default.
- W2928770856 hasBestOaLocation W29287708561 @default.
- W2928770856 hasConcept C104966671 @default.
- W2928770856 hasConcept C126322002 @default.
- W2928770856 hasConcept C15744967 @default.
- W2928770856 hasConcept C169760540 @default.
- W2928770856 hasConcept C169900460 @default.
- W2928770856 hasConcept C185711340 @default.
- W2928770856 hasConcept C22885893 @default.
- W2928770856 hasConcept C24998067 @default.
- W2928770856 hasConcept C2775858765 @default.
- W2928770856 hasConcept C2778205193 @default.
- W2928770856 hasConcept C2778542668 @default.
- W2928770856 hasConcept C2779134260 @default.
- W2928770856 hasConcept C2779734285 @default.
- W2928770856 hasConcept C2985665543 @default.
- W2928770856 hasConcept C71924100 @default.
- W2928770856 hasConceptScore W2928770856C104966671 @default.
- W2928770856 hasConceptScore W2928770856C126322002 @default.
- W2928770856 hasConceptScore W2928770856C15744967 @default.
- W2928770856 hasConceptScore W2928770856C169760540 @default.
- W2928770856 hasConceptScore W2928770856C169900460 @default.
- W2928770856 hasConceptScore W2928770856C185711340 @default.
- W2928770856 hasConceptScore W2928770856C22885893 @default.
- W2928770856 hasConceptScore W2928770856C24998067 @default.
- W2928770856 hasConceptScore W2928770856C2775858765 @default.
- W2928770856 hasConceptScore W2928770856C2778205193 @default.
- W2928770856 hasConceptScore W2928770856C2778542668 @default.
- W2928770856 hasConceptScore W2928770856C2779134260 @default.
- W2928770856 hasConceptScore W2928770856C2779734285 @default.
- W2928770856 hasConceptScore W2928770856C2985665543 @default.
- W2928770856 hasConceptScore W2928770856C71924100 @default.
- W2928770856 hasLocation W29287708561 @default.
- W2928770856 hasOpenAccess W2928770856 @default.
- W2928770856 hasPrimaryLocation W29287708561 @default.
- W2928770856 hasRelatedWork W1550155560 @default.
- W2928770856 hasRelatedWork W1964756308 @default.
- W2928770856 hasRelatedWork W1967350022 @default.
- W2928770856 hasRelatedWork W1970877033 @default.
- W2928770856 hasRelatedWork W1977150364 @default.
- W2928770856 hasRelatedWork W1990485114 @default.
- W2928770856 hasRelatedWork W2039455133 @default.
- W2928770856 hasRelatedWork W2069194367 @default.
- W2928770856 hasRelatedWork W2071357170 @default.
- W2928770856 hasRelatedWork W2089655624 @default.
- W2928770856 hasRelatedWork W2117779779 @default.
- W2928770856 hasRelatedWork W2120037206 @default.
- W2928770856 hasRelatedWork W2157382515 @default.
- W2928770856 hasRelatedWork W2238263898 @default.
- W2928770856 hasRelatedWork W2472530303 @default.
- W2928770856 hasRelatedWork W2550438468 @default.
- W2928770856 hasRelatedWork W2737484458 @default.
- W2928770856 hasRelatedWork W2793001015 @default.
- W2928770856 hasRelatedWork W2084612211 @default.
- W2928770856 hasRelatedWork W2407409554 @default.
- W2928770856 isParatext "false" @default.
- W2928770856 isRetracted "false" @default.
- W2928770856 magId "2928770856" @default.
- W2928770856 workType "article" @default.