FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2928777130> ?p ?o ?g. }

• W2928777130 endingPage "483" @default.
• W2928777130 startingPage "475" @default.
• W2928777130 abstract "The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX 21 in two model systems: a human whole blood ex vivo model and a murine in vivo peritoneum model – both reflecting early innate immune response. In the whole blood model, LTX 21 increased the secretion of a range of different cytokines, decreased the level of tumour necrosis factor ( TNF ) and activated the complement system. In a haemolysis assay, we found 2.5% haemolysis at a LTX 21 concentration of 500 mg/L. In the murine model, increased influx of white blood cells ( WBC s) and polymorphonuclear neutrophils ( PMN s) in the murine peritoneal cavity was observed after treatment with LTX 21. In addition, LTX 21 increased monocyte chemoattractant protein‐1 ( MCP ‐1). In conclusion, LTX 21 affected the inflammatory response; the increase in cytokine secretion, complement activation and WBC influx indicates an activated inflammatory response. The present results indicate the impact of LTX 21 on the host–pathogen interplay. Whether this will also affect the course of infection has to be investigated." @default.
• W2928777130 created "2019-04-11" @default.
• W2928777130 creator A5020753201 @default.
• W2928777130 creator A5026817720 @default.
• W2928777130 creator A5034439136 @default.
• W2928777130 creator A5040137110 @default.
• W2928777130 creator A5050246861 @default.
• W2928777130 creator A5057441998 @default.
• W2928777130 creator A5061029150 @default.
• W2928777130 creator A5064415290 @default.
• W2928777130 creator A5073840912 @default.
• W2928777130 creator A5078785268 @default.
• W2928777130 date "2019-04-26" @default.
• W2928777130 modified "2023-10-16" @default.
• W2928777130 title "The synthetic antimicrobial peptide LTX 21 induces inflammatory responses in a human whole blood model and a murine peritoneum model" @default.
• W2928777130 cites W1048494823 @default.
• W2928777130 cites W1484992502 @default.
• W2928777130 cites W1578893636 @default.
• W2928777130 cites W1960761101 @default.
• W2928777130 cites W1966727637 @default.
• W2928777130 cites W1981664793 @default.
• W2928777130 cites W1992542859 @default.
• W2928777130 cites W1998027562 @default.
• W2928777130 cites W2018382434 @default.
• W2928777130 cites W2037178359 @default.
• W2928777130 cites W2039820190 @default.
• W2928777130 cites W2040733257 @default.
• W2928777130 cites W2043952376 @default.
• W2928777130 cites W2061729543 @default.
• W2928777130 cites W2067311110 @default.
• W2928777130 cites W2076153232 @default.
• W2928777130 cites W2080086899 @default.
• W2928777130 cites W2080417514 @default.
• W2928777130 cites W2090184229 @default.
• W2928777130 cites W2091868193 @default.
• W2928777130 cites W2099042559 @default.
• W2928777130 cites W2102823978 @default.
• W2928777130 cites W2115495670 @default.
• W2928777130 cites W2137520143 @default.
• W2928777130 cites W2138207315 @default.
• W2928777130 cites W2146999020 @default.
• W2928777130 cites W2147684469 @default.
• W2928777130 cites W2151826099 @default.
• W2928777130 cites W2151943864 @default.
• W2928777130 cites W2152466791 @default.
• W2928777130 cites W2153647188 @default.
• W2928777130 cites W2162846990 @default.
• W2928777130 cites W2168442227 @default.
• W2928777130 cites W2171047304 @default.
• W2928777130 cites W2189137321 @default.
• W2928777130 cites W2197072220 @default.
• W2928777130 cites W2315594095 @default.
• W2928777130 cites W2337957188 @default.
• W2928777130 cites W4243514341 @default.
• W2928777130 doi "https://doi.org/10.1111/apm.12946" @default.
• W2928777130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30916807" @default.
• W2928777130 hasPublicationYear "2019" @default.
• W2928777130 type Work @default.
• W2928777130 sameAs 2928777130 @default.
• W2928777130 citedByCount "2" @default.
• W2928777130 countsByYear W29287771302020 @default.
• W2928777130 countsByYear W29287771302022 @default.
• W2928777130 crossrefType "journal-article" @default.
• W2928777130 hasAuthorship W2928777130A5020753201 @default.
• W2928777130 hasAuthorship W2928777130A5026817720 @default.
• W2928777130 hasAuthorship W2928777130A5034439136 @default.
• W2928777130 hasAuthorship W2928777130A5040137110 @default.
• W2928777130 hasAuthorship W2928777130A5050246861 @default.
• W2928777130 hasAuthorship W2928777130A5057441998 @default.
• W2928777130 hasAuthorship W2928777130A5061029150 @default.
• W2928777130 hasAuthorship W2928777130A5064415290 @default.
• W2928777130 hasAuthorship W2928777130A5073840912 @default.
• W2928777130 hasAuthorship W2928777130A5078785268 @default.
• W2928777130 hasBestOaLocation W29287771302 @default.
• W2928777130 hasConcept C111684460 @default.
• W2928777130 hasConcept C136449434 @default.
• W2928777130 hasConcept C142724271 @default.
• W2928777130 hasConcept C150903083 @default.
• W2928777130 hasConcept C17991360 @default.
• W2928777130 hasConcept C203014093 @default.
• W2928777130 hasConcept C207001950 @default.
• W2928777130 hasConcept C26291073 @default.
• W2928777130 hasConcept C2776001837 @default.
• W2928777130 hasConcept C2778690821 @default.
• W2928777130 hasConcept C2781184567 @default.
• W2928777130 hasConcept C2910801743 @default.
• W2928777130 hasConcept C4937899 @default.
• W2928777130 hasConcept C71924100 @default.
• W2928777130 hasConcept C86803240 @default.
• W2928777130 hasConcept C8891405 @default.
• W2928777130 hasConcept C89423630 @default.
• W2928777130 hasConceptScore W2928777130C111684460 @default.
• W2928777130 hasConceptScore W2928777130C136449434 @default.
• W2928777130 hasConceptScore W2928777130C142724271 @default.
• W2928777130 hasConceptScore W2928777130C150903083 @default.
• W2928777130 hasConceptScore W2928777130C17991360 @default.
• W2928777130 hasConceptScore W2928777130C203014093 @default.
• W2928777130 hasConceptScore W2928777130C207001950 @default.

• next