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- W2928829047 abstract "Abstract Two stability-indicating assay methods, HPLC-DAD and HPTLC, for analyzing amiloride hydrochloride, AMI, and cyclopenthiazide, CYPZ, have been developed. The drugs were subjected to forced thermal, chemical and photo-degradation conditions including acidic, basic and neutral hydrolysis, oxidation, dry heat, and photolysis. The drugs were resolved from their forced-degradation products. The kinetics of degradation was studied using Arrhenius plot followed by calculation of the activation energy and half-life at room temperature. The t1/2 values at room temperature of AMI were found to be 12.881, 3.094, 13.805 and 16.902 h while for CYPZ were 5.63, 7.65, 13.72 and 30.13 h at acidic, alkaline, neutral and oxidative degradation. The purity of the parent drugs peaks was confirmed using the peak purity tools in HPLC-DAD and HPTLC." @default.
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- W2928829047 date "2019-06-01" @default.
- W2928829047 modified "2023-09-26" @default.
- W2928829047 title "The use of Arrhenius kinetics to evaluate different hydrolytic stability of amiloride hydrochloride and cyclopenthiazide using chromatographic methods" @default.
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- W2928829047 doi "https://doi.org/10.1016/j.microc.2019.03.073" @default.
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