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• W29290466 startingPage "2167" @default.
• W29290466 abstract "The Saccharomyces cerevisiae gene CDC6, whose protein product is required for DNA replication, is transcribed only in late G1 and S phases. We have discovered a critical reason why CDC6 expression is regulated in this fashion. Constitutive CDC6 transcription greatly delayed the initiation of M phase without effecting the G1-S transition or growth rate. This occurred in both fission and budding yeasts. The CDC6-induced M phase delay was dependent on the wee1/mik1 mitotic inhibitor kinases and was greatly accentuated in strains defective for the cdc25/MIH1 mitotic inducer phosphatases, indicating that CDC6 indirectly inhibits activation of the p34cdc2/CDC28 M phase kinase. Thus CDC6 appears to have an important and perhaps unique dual role in S phase, it is first required for the initiation of DNA replication and then actively participates in the suppression of nuclear division." @default.
• W29290466 created "2016-06-24" @default.
• W29290466 creator A5012431295 @default.
• W29290466 creator A5058529935 @default.
• W29290466 date "1992-06-01" @default.
• W29290466 modified "2023-10-15" @default.
• W29290466 title "Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division." @default.
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• W29290466 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05276.x" @default.
• W29290466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556684" @default.
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• W29290466 hasPublicationYear "1992" @default.
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