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- W2929129914 abstract "Abstract Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide and small indels, creating a large catalog of genomic variation for a companion animal species. We undertake both selective sweep analyses and genome wide association studies (GWAS) inclusive of over 144 modern breeds, 54 wild canids and a hundred village dogs. Our results identify variants of strong impact associated with 16 phenotypes, including body weight variation which, when combined with existing data, explain greater than 90% of body size variation in dogs. We thus demonstrate that GWAS and selection scans performed with WGS are powerful complementary methods for expanding the utility of companion animal systems for the study of mammalian growth and biology." @default.
- W2929129914 created "2019-04-11" @default.
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- W2929129914 date "2019-04-02" @default.
- W2929129914 modified "2023-10-15" @default.
- W2929129914 title "Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology" @default.
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- W2929129914 doi "https://doi.org/10.1038/s41467-019-09373-w" @default.
- W2929129914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6445083" @default.
- W2929129914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30940804" @default.
- W2929129914 hasPublicationYear "2019" @default.
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