FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2929486546> ?p ?o ?g. }

• W2929486546 endingPage "461" @default.
• W2929486546 startingPage "461" @default.
• W2929486546 abstract "Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions within the tumor microenvironment (TME). Some of these aberrant functions include attenuation of targeting and killing of tumor cells, tolerogenic/immunosuppressive behavior and acquisition of pro-angiogenic activities. Natural killer (NK) cells are effector lymphocytes involved in tumor immunosurveillance. In solid malignancies, tumor-associated NK cells (TANK cells) in peripheral blood and tumor-infiltrating NK (TINK) cells show altered phenotypes and are characterized by either anergy or reduced cytotoxicity. Here, we aim at discussing how NK cells can support tumor progression and how induction of angiogenesis, due to TME stimuli, can be a relevant part on the NK cell-associated tumor supporting activities. We will review and discuss the contribution of the TME in shaping NK cell response favoring cancer progression. We will focus on TME-derived set of factors such as TGF-β, soluble HLA-G, prostaglandin E2, adenosine, extracellular vesicles, and miRNAs, which can exhibit a dual function. On one hand, these factors can suppress NK cell-mediated activities but, on the other hand, they can induce a pro-angiogenic polarization in NK cells. Also, we will analyze the impact on cancer progression of the interaction of NK cells with several TME-associated cells, including macrophages, neutrophils, mast cells, cancer-associated fibroblasts, and endothelial cells. Then, we will discuss the most relevant therapeutic approaches aimed at potentiating/restoring NK cell activities against tumors. Finally, supported by the literature revision and our new findings on NK cell pro-angiogenic activities, we uphold NK cells to a key host cellular paradigm in controlling tumor progression and angiogenesis; thus, we should bear in mind NK cells like a TME-associated target for anti-tumor therapeutic approaches." @default.
• W2929486546 created "2019-04-11" @default.
• W2929486546 creator A5009148538 @default.
• W2929486546 creator A5009460285 @default.
• W2929486546 creator A5023598157 @default.
• W2929486546 creator A5039450174 @default.
• W2929486546 creator A5045982942 @default.
• W2929486546 creator A5065295889 @default.
• W2929486546 date "2019-04-01" @default.
• W2929486546 modified "2023-10-01" @default.
• W2929486546 title "Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects" @default.
• W2929486546 cites W1261949646 @default.
• W2929486546 cites W132217434 @default.
• W2929486546 cites W138410924 @default.
• W2929486546 cites W1491173757 @default.
• W2929486546 cites W1497331930 @default.
• W2929486546 cites W1509093479 @default.
• W2929486546 cites W1511635744 @default.
• W2929486546 cites W1537481688 @default.
• W2929486546 cites W1555729280 @default.
• W2929486546 cites W1556664229 @default.
• W2929486546 cites W1571520647 @default.
• W2929486546 cites W1576414450 @default.
• W2929486546 cites W1583109269 @default.
• W2929486546 cites W1591236327 @default.
• W2929486546 cites W1599718730 @default.
• W2929486546 cites W1671560425 @default.
• W2929486546 cites W1675343160 @default.
• W2929486546 cites W1761567378 @default.
• W2929486546 cites W1772986380 @default.
• W2929486546 cites W1786051985 @default.
• W2929486546 cites W1798331267 @default.
• W2929486546 cites W1894510512 @default.
• W2929486546 cites W1910995500 @default.
• W2929486546 cites W1916893403 @default.
• W2929486546 cites W1966243735 @default.
• W2929486546 cites W1967455230 @default.
• W2929486546 cites W1968321644 @default.
• W2929486546 cites W1969536528 @default.
• W2929486546 cites W1969814796 @default.
• W2929486546 cites W1972196680 @default.
• W2929486546 cites W1972825083 @default.
• W2929486546 cites W1973852067 @default.
• W2929486546 cites W1973999018 @default.
• W2929486546 cites W1974954833 @default.
• W2929486546 cites W1976527118 @default.
• W2929486546 cites W1977957489 @default.
• W2929486546 cites W1982693713 @default.
• W2929486546 cites W1984162437 @default.
• W2929486546 cites W1985322758 @default.
• W2929486546 cites W1985576417 @default.
• W2929486546 cites W1985638936 @default.
• W2929486546 cites W1986321004 @default.
• W2929486546 cites W1990265423 @default.
• W2929486546 cites W1990412862 @default.
• W2929486546 cites W1991849405 @default.
• W2929486546 cites W1995515999 @default.
• W2929486546 cites W1997011364 @default.
• W2929486546 cites W2002595222 @default.
• W2929486546 cites W2003388948 @default.
• W2929486546 cites W2005203470 @default.
• W2929486546 cites W2006350053 @default.
• W2929486546 cites W2007173888 @default.
• W2929486546 cites W2008932880 @default.
• W2929486546 cites W2009189697 @default.
• W2929486546 cites W2009402396 @default.
• W2929486546 cites W2012886748 @default.
• W2929486546 cites W2012959199 @default.
• W2929486546 cites W2013743238 @default.
• W2929486546 cites W2014135188 @default.
• W2929486546 cites W2015222608 @default.
• W2929486546 cites W2016523043 @default.
• W2929486546 cites W2018922991 @default.
• W2929486546 cites W2019750756 @default.
• W2929486546 cites W2020404158 @default.
• W2929486546 cites W2022580424 @default.
• W2929486546 cites W2023319194 @default.
• W2929486546 cites W2025950737 @default.
• W2929486546 cites W2029458815 @default.
• W2929486546 cites W2030272844 @default.
• W2929486546 cites W2030381568 @default.
• W2929486546 cites W2033278321 @default.
• W2929486546 cites W2033289727 @default.
• W2929486546 cites W2036810329 @default.
• W2929486546 cites W2037742773 @default.
• W2929486546 cites W2038884900 @default.
• W2929486546 cites W2044179999 @default.
• W2929486546 cites W2044360617 @default.
• W2929486546 cites W2044946329 @default.
• W2929486546 cites W2047976284 @default.
• W2929486546 cites W2048250100 @default.
• W2929486546 cites W2049273306 @default.
• W2929486546 cites W2049656655 @default.
• W2929486546 cites W2052432945 @default.
• W2929486546 cites W2052502668 @default.
• W2929486546 cites W2053330214 @default.
• W2929486546 cites W2054526193 @default.
• W2929486546 cites W2054661897 @default.

• next