FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2929573126> ?p ?o ?g. }

• W2929573126 abstract "Glia are key regulators of inflammatory responses within the central nervous system (CNS) following infection or trauma. We have previously demonstrated the ability of activated glia to rapidly produce pro-inflammatory mediators followed by a transition to an anti-inflammatory cytokine production profile that includes the immunosuppressive cytokine interleukin (IL)-10 and the closely related cytokine IL-19. IL-24, another member of the IL-10 family, has been studied in a number of inflammatory conditions in the periphery and is known to modulate immune cell activity. However, the ability of glia to produce IL-24 remains unclear and the effects of this pleiotropic cytokine on glial immune functions have not been investigated. In this study, we have assessed whether primary murine glia produce IL-24 following stimulation and evaluated the effect of this cytokine on the immune responses of such cells. We have utilized RT-PCR and immunoblot analyses to assess the expression of IL-24 and its cognate receptors by astrocytes following challenge with bacteria or their components. Furthermore, we have determined the effect of recombinant IL-24 on astrocyte immune signaling and responses to clinically relevant bacteria using RT-PCR and specific capture ELISAs. We demonstrate that astrocytes express IL-24 mRNA and release detectable amounts of this cytokine protein in a delayed manner following bacterial challenge. In addition, we have determined that glia constitutively express the cognate receptors for IL-24 and show that such expression can be increased in astrocytes following activation. Importantly, our results indicate that IL-24 exerts an immunosuppressive effect on astrocytes by elevating suppressor of cytokine signaling 3 expression and limiting IL-6 production following challenge. Furthermore, we have demonstrated that IL-24 can also augment the release of IL-10 by bacterially challenged astrocytes and can induce the expression of the potentially neuroprotective mediators, glutamate transporter 1, and cyclooxygenase 2. The expression of IL-24 and its cognate receptors by astrocytes following bacterial challenge, and the ability of this cytokine to limit inflammatory responses while promoting the expression of immunosuppressive and/or neuroprotective mediators, raises the intriguing possibility that IL-24 functions to regulate or resolve CNS inflammation following bacterial infection in order to limit neuronal damage." @default.
• W2929573126 created "2019-04-11" @default.
• W2929573126 creator A5002135869 @default.
• W2929573126 creator A5034508784 @default.
• W2929573126 creator A5061095411 @default.
• W2929573126 creator A5074784700 @default.
• W2929573126 date "2019-03-02" @default.
• W2929573126 modified "2023-10-18" @default.
• W2929573126 title "Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine" @default.
• W2929573126 cites W1495790818 @default.
• W2929573126 cites W1539392991 @default.
• W2929573126 cites W1581636546 @default.
• W2929573126 cites W1601132847 @default.
• W2929573126 cites W1902294189 @default.
• W2929573126 cites W1908956977 @default.
• W2929573126 cites W1953077261 @default.
• W2929573126 cites W1955488889 @default.
• W2929573126 cites W1967551645 @default.
• W2929573126 cites W1968532804 @default.
• W2929573126 cites W1981408589 @default.
• W2929573126 cites W1991538811 @default.
• W2929573126 cites W1999569536 @default.
• W2929573126 cites W2000329187 @default.
• W2929573126 cites W2007147818 @default.
• W2929573126 cites W2019483546 @default.
• W2929573126 cites W2023353555 @default.
• W2929573126 cites W2054551045 @default.
• W2929573126 cites W2054939271 @default.
• W2929573126 cites W2055219365 @default.
• W2929573126 cites W2065565273 @default.
• W2929573126 cites W2066384268 @default.
• W2929573126 cites W2083576842 @default.
• W2929573126 cites W2083666225 @default.
• W2929573126 cites W2103912225 @default.
• W2929573126 cites W2108851815 @default.
• W2929573126 cites W2121039744 @default.
• W2929573126 cites W2129935236 @default.
• W2929573126 cites W2131474520 @default.
• W2929573126 cites W2132493492 @default.
• W2929573126 cites W2146247267 @default.
• W2929573126 cites W2154646056 @default.
• W2929573126 cites W2162098634 @default.
• W2929573126 cites W2165578318 @default.
• W2929573126 cites W2337292079 @default.
• W2929573126 cites W2560085321 @default.
• W2929573126 cites W2574949547 @default.
• W2929573126 cites W2744370763 @default.
• W2929573126 cites W2769458157 @default.
• W2929573126 cites W2773263734 @default.
• W2929573126 cites W2779662615 @default.
• W2929573126 cites W2787894998 @default.
• W2929573126 doi "https://doi.org/10.1186/s12974-019-1444-1" @default.
• W2929573126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397747" @default.
• W2929573126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30825881" @default.
• W2929573126 hasPublicationYear "2019" @default.
• W2929573126 type Work @default.
• W2929573126 sameAs 2929573126 @default.
• W2929573126 citedByCount "9" @default.
• W2929573126 countsByYear W29295731262019 @default.
• W2929573126 countsByYear W29295731262020 @default.
• W2929573126 countsByYear W29295731262021 @default.
• W2929573126 countsByYear W29295731262022 @default.
• W2929573126 countsByYear W29295731262023 @default.
• W2929573126 crossrefType "journal-article" @default.
• W2929573126 hasAuthorship W2929573126A5002135869 @default.
• W2929573126 hasAuthorship W2929573126A5034508784 @default.
• W2929573126 hasAuthorship W2929573126A5061095411 @default.
• W2929573126 hasAuthorship W2929573126A5074784700 @default.
• W2929573126 hasBestOaLocation W29295731261 @default.
• W2929573126 hasConcept C11988809 @default.
• W2929573126 hasConcept C169760540 @default.
• W2929573126 hasConcept C170493617 @default.
• W2929573126 hasConcept C17991360 @default.
• W2929573126 hasConcept C201934248 @default.
• W2929573126 hasConcept C203014093 @default.
• W2929573126 hasConcept C2776914184 @default.
• W2929573126 hasConcept C2777542381 @default.
• W2929573126 hasConcept C2778690821 @default.
• W2929573126 hasConcept C2779830541 @default.
• W2929573126 hasConcept C529278444 @default.
• W2929573126 hasConcept C55493867 @default.
• W2929573126 hasConcept C86803240 @default.
• W2929573126 hasConcept C87753298 @default.
• W2929573126 hasConcept C8891405 @default.
• W2929573126 hasConcept C95444343 @default.
• W2929573126 hasConceptScore W2929573126C11988809 @default.
• W2929573126 hasConceptScore W2929573126C169760540 @default.
• W2929573126 hasConceptScore W2929573126C170493617 @default.
• W2929573126 hasConceptScore W2929573126C17991360 @default.
• W2929573126 hasConceptScore W2929573126C201934248 @default.
• W2929573126 hasConceptScore W2929573126C203014093 @default.
• W2929573126 hasConceptScore W2929573126C2776914184 @default.
• W2929573126 hasConceptScore W2929573126C2777542381 @default.
• W2929573126 hasConceptScore W2929573126C2778690821 @default.
• W2929573126 hasConceptScore W2929573126C2779830541 @default.
• W2929573126 hasConceptScore W2929573126C529278444 @default.
• W2929573126 hasConceptScore W2929573126C55493867 @default.
• W2929573126 hasConceptScore W2929573126C86803240 @default.
• W2929573126 hasConceptScore W2929573126C87753298 @default.
• W2929573126 hasConceptScore W2929573126C8891405 @default.

• next