Matches in SemOpenAlex for { <https://semopenalex.org/work/W2929702996> ?p ?o ?g. }
- W2929702996 endingPage "322" @default.
- W2929702996 startingPage "318" @default.
- W2929702996 abstract "Background Intermediate-dose cytarabine plus G-CSF has recently emerged as safe and effective mobilization regimen for heavily pre-treated patients with lymphoid malignancies. We prospectively tested this regimen in patients referred to our center in order to collect enough stem cells for hematopoietic rescue in autologous transplantation (auto-HSCT). Study design and methods cytarabine (1.6 g/m2) plus G-CSF (outpatient administration) was performed in 81 consecutive patients who underwent auto-HSCT. For analyses purposes patients were divided into Group A, consisted of 48 patients with newly diagnosed multiple myeloma (MM) and Group B with 33 heavily pre-treated patients (13 Hodgkin´s lymphoma, 7 non-Hodgkin´s lymphoma, 7 MM, 4 germ cell tumor, 2 non-promyelocytic acute myeloid leukemia). Results In the Group A, circulating CD34+ cells/μL was significantly higher, 90% started stem cell harvest on day 14, 98% collected ≥5.0 × 106 CD34+cells/kg and a single apheresis was sufficient in 92% of the cases. In the Group B, 85% started leukapheresis on day 14, 88% collected ≥2.0 × 106 CD34+cells/kg which was achieved with a single apheresis in 82% of the cases; a higher proportion of the patients (63.6% versus 33.3%) required platelet transfusions. Both groups exhibited few adverse events and the time to neutrophil and platelet recovery was similar between groups. Conclusion Intermediate-dose cytarabine plus G-CSF mobilization is effective even for heavily pre-treated patients. The outpatient administration of G-CSF, the reliable prediction of the day to begin harvesting, the optimal CD34+ cell yield obtained with a single apheresis and the fewer occurrences of adverse events denoted the benefits of this regimen." @default.
- W2929702996 created "2019-04-11" @default.
- W2929702996 creator A5007578280 @default.
- W2929702996 creator A5024389997 @default.
- W2929702996 creator A5039469103 @default.
- W2929702996 date "2019-06-01" @default.
- W2929702996 modified "2023-10-18" @default.
- W2929702996 title "Intermediate-dose cytarabine plus G-CSF as mobilization regimen for newly diagnosed multiple myeloma and heavily pre-treated patients with hematological and non-hematological malignancies" @default.
- W2929702996 cites W1965346693 @default.
- W2929702996 cites W1969858222 @default.
- W2929702996 cites W1990778014 @default.
- W2929702996 cites W2016170843 @default.
- W2929702996 cites W2029886313 @default.
- W2929702996 cites W2083668015 @default.
- W2929702996 cites W2088302043 @default.
- W2929702996 cites W2121735943 @default.
- W2929702996 cites W2139834228 @default.
- W2929702996 cites W2152801965 @default.
- W2929702996 cites W2170762893 @default.
- W2929702996 cites W2180205512 @default.
- W2929702996 cites W2625865878 @default.
- W2929702996 cites W3186185206 @default.
- W2929702996 doi "https://doi.org/10.1016/j.transci.2019.03.018" @default.
- W2929702996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30961974" @default.
- W2929702996 hasPublicationYear "2019" @default.
- W2929702996 type Work @default.
- W2929702996 sameAs 2929702996 @default.
- W2929702996 citedByCount "2" @default.
- W2929702996 countsByYear W29297029962022 @default.
- W2929702996 crossrefType "journal-article" @default.
- W2929702996 hasAuthorship W2929702996A5007578280 @default.
- W2929702996 hasAuthorship W2929702996A5024389997 @default.
- W2929702996 hasAuthorship W2929702996A5039469103 @default.
- W2929702996 hasConcept C10205521 @default.
- W2929702996 hasConcept C126322002 @default.
- W2929702996 hasConcept C129470790 @default.
- W2929702996 hasConcept C13373296 @default.
- W2929702996 hasConcept C141071460 @default.
- W2929702996 hasConcept C170493617 @default.
- W2929702996 hasConcept C197934379 @default.
- W2929702996 hasConcept C2776364478 @default.
- W2929702996 hasConcept C2776694085 @default.
- W2929702996 hasConcept C2776738589 @default.
- W2929702996 hasConcept C2777371436 @default.
- W2929702996 hasConcept C2777408962 @default.
- W2929702996 hasConcept C2777767877 @default.
- W2929702996 hasConcept C2778041864 @default.
- W2929702996 hasConcept C2778828106 @default.
- W2929702996 hasConcept C2779050716 @default.
- W2929702996 hasConcept C2779282312 @default.
- W2929702996 hasConcept C2781413609 @default.
- W2929702996 hasConcept C28328180 @default.
- W2929702996 hasConcept C2911091166 @default.
- W2929702996 hasConcept C54355233 @default.
- W2929702996 hasConcept C71924100 @default.
- W2929702996 hasConcept C86803240 @default.
- W2929702996 hasConcept C89560881 @default.
- W2929702996 hasConcept C90924648 @default.
- W2929702996 hasConceptScore W2929702996C10205521 @default.
- W2929702996 hasConceptScore W2929702996C126322002 @default.
- W2929702996 hasConceptScore W2929702996C129470790 @default.
- W2929702996 hasConceptScore W2929702996C13373296 @default.
- W2929702996 hasConceptScore W2929702996C141071460 @default.
- W2929702996 hasConceptScore W2929702996C170493617 @default.
- W2929702996 hasConceptScore W2929702996C197934379 @default.
- W2929702996 hasConceptScore W2929702996C2776364478 @default.
- W2929702996 hasConceptScore W2929702996C2776694085 @default.
- W2929702996 hasConceptScore W2929702996C2776738589 @default.
- W2929702996 hasConceptScore W2929702996C2777371436 @default.
- W2929702996 hasConceptScore W2929702996C2777408962 @default.
- W2929702996 hasConceptScore W2929702996C2777767877 @default.
- W2929702996 hasConceptScore W2929702996C2778041864 @default.
- W2929702996 hasConceptScore W2929702996C2778828106 @default.
- W2929702996 hasConceptScore W2929702996C2779050716 @default.
- W2929702996 hasConceptScore W2929702996C2779282312 @default.
- W2929702996 hasConceptScore W2929702996C2781413609 @default.
- W2929702996 hasConceptScore W2929702996C28328180 @default.
- W2929702996 hasConceptScore W2929702996C2911091166 @default.
- W2929702996 hasConceptScore W2929702996C54355233 @default.
- W2929702996 hasConceptScore W2929702996C71924100 @default.
- W2929702996 hasConceptScore W2929702996C86803240 @default.
- W2929702996 hasConceptScore W2929702996C89560881 @default.
- W2929702996 hasConceptScore W2929702996C90924648 @default.
- W2929702996 hasIssue "3" @default.
- W2929702996 hasLocation W29297029961 @default.
- W2929702996 hasLocation W29297029962 @default.
- W2929702996 hasOpenAccess W2929702996 @default.
- W2929702996 hasPrimaryLocation W29297029961 @default.
- W2929702996 hasRelatedWork W1508913838 @default.
- W2929702996 hasRelatedWork W1572109053 @default.
- W2929702996 hasRelatedWork W1895328588 @default.
- W2929702996 hasRelatedWork W2022355235 @default.
- W2929702996 hasRelatedWork W2156425432 @default.
- W2929702996 hasRelatedWork W2548975104 @default.
- W2929702996 hasRelatedWork W2979715556 @default.
- W2929702996 hasRelatedWork W2994838078 @default.
- W2929702996 hasRelatedWork W4247486082 @default.
- W2929702996 hasRelatedWork W4293796804 @default.