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- W2930003603 abstract "Ribosome biogenesis (RiBi) is an extremely energy intensive process that is critical for gene expression. It is thus highly regulated, including through the tightly coordinated expression of over 200 RiBi genes by positive and negative transcriptional regulators. We investigated RiBi regulation as cells initiated meiosis in budding yeast and noted early transcriptional activation of RiBi genes, followed by their apparent translational repression 1 hour (h) after stimulation to enter meiosis. Surprisingly, in the representative genes examined, measured translational repression depended on their promoters rather than mRNA regions. Further investigation revealed that the signature of this regulation in our data depended on pre-treating cells with the translation inhibitor, cycloheximide (CHX). This treatment, at 1 h in meiosis, but not earlier, rapidly resulted in accumulation of RiBi mRNAs that were not translated. This effect was also seen in with CHX pre-treatment of cells grown in media lacking amino acids. For NSR1, this effect depended on the –150 to –101 region of the promoter, as well as the RiBi transcriptional repressors Dot6 and Tod6. Condition-specific RiBi mRNA accumulation was also seen with translation inhibitors that are dissimilar from CHX, suggesting that this phenomenon might represent a feedback response to global translation inhibition." @default.
- W2930003603 created "2019-04-11" @default.
- W2930003603 creator A5012675519 @default.
- W2930003603 creator A5058972457 @default.
- W2930003603 date "2019-04-02" @default.
- W2930003603 modified "2023-09-24" @default.
- W2930003603 title "Global translation inhibition yields condition-dependent de-repression of ribosome biogenesis mRNAs" @default.
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- W2930003603 doi "https://doi.org/10.1093/nar/gkz231" @default.
- W2930003603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6547411" @default.
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