FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2930082868> ?p ?o ?g. }

• W2930082868 endingPage "142" @default.
• W2930082868 startingPage "134" @default.
• W2930082868 abstract "Ambient ionization in open environment brings a capability of a coupled mass spectrometry to detect target molecules in situ. However, it is limited to qualitative and semi-quantitative analysis. By coupling of an ambient ionization-based Direct Analysis in Real Time (DART) with high-resolution quadrupole time-of-flight mass spectrometry (QTOF/MS), we observe that, in one-chemical system, the target molecule displays a non-linear response in MS signal vs concentration, accompanying with large variation in MS signal, suggesting two obstacles for quantification to be overcome. Surprisingly, in a two-chemical system, we observe an apparent suppression effect. We prove that, due to this observed suppression effect, a fluctuant response in the MS signal of the stable isotope-labeled analogue can immediately reflect the change in the analyte concentration and ionization efficiency. For example, by taking advantage of this effect, even the analyte of different concentrations despairingly displayed similar signals would be accurately calibrated through the suppression of the internal stable isotope standard. This puts an important foundation on accurate and linear quantitation of analytes in complex matrix using DART-MS assay. Moreover, we for the first time demonstrate an application of in situ calibration of DART-MS for direct and accurate quantification of target molecule (creatinine) in highly complex samples (human urine) without any pre-separation. The quantification is also validated using HPLC-UV analysis (n = 38). At last, we show that stable isotope-labeled-creatinine (m/z 117.0850 amu) can be used for simultaneous in situ calibration of some other urinary metabolites with a mass/charge ratio varying from 120.069 amu to 333.125 amu." @default.
• W2930082868 created "2019-04-11" @default.
• W2930082868 creator A5008405013 @default.
• W2930082868 creator A5011339475 @default.
• W2930082868 creator A5037096872 @default.
• W2930082868 creator A5054418515 @default.
• W2930082868 creator A5064642859 @default.
• W2930082868 date "2019-08-01" @default.
• W2930082868 modified "2023-10-14" @default.
• W2930082868 title "In situ calibration of Direct Analysis in Real Time-mass spectrometry for direct quantification: Urine excretion rate index creatinine as an example" @default.
• W2930082868 cites W1040363138 @default.
• W2930082868 cites W1556599425 @default.
• W2930082868 cites W1574264135 @default.
• W2930082868 cites W1964043583 @default.
• W2930082868 cites W1964086670 @default.
• W2930082868 cites W1981910484 @default.
• W2930082868 cites W1984841061 @default.
• W2930082868 cites W1985284360 @default.
• W2930082868 cites W1987424998 @default.
• W2930082868 cites W1990958226 @default.
• W2930082868 cites W1991080558 @default.
• W2930082868 cites W1995507935 @default.
• W2930082868 cites W1995984700 @default.
• W2930082868 cites W1996816716 @default.
• W2930082868 cites W2000203039 @default.
• W2930082868 cites W2000694067 @default.
• W2930082868 cites W2002200543 @default.
• W2930082868 cites W2014334966 @default.
• W2930082868 cites W2017762518 @default.
• W2930082868 cites W2018533952 @default.
• W2930082868 cites W2020935684 @default.
• W2930082868 cites W2029328411 @default.
• W2930082868 cites W2031248851 @default.
• W2930082868 cites W2036789134 @default.
• W2930082868 cites W2037155452 @default.
• W2930082868 cites W2044323589 @default.
• W2930082868 cites W2048702612 @default.
• W2930082868 cites W2048885369 @default.
• W2930082868 cites W2053591916 @default.
• W2930082868 cites W2059559754 @default.
• W2930082868 cites W2060637040 @default.
• W2930082868 cites W2061107331 @default.
• W2930082868 cites W2063686788 @default.
• W2930082868 cites W2065395390 @default.
• W2930082868 cites W2069932077 @default.
• W2930082868 cites W2072229469 @default.
• W2930082868 cites W2072230060 @default.
• W2930082868 cites W2074461222 @default.
• W2930082868 cites W2079826151 @default.
• W2930082868 cites W2080887655 @default.
• W2930082868 cites W2081379318 @default.
• W2930082868 cites W2081724030 @default.
• W2930082868 cites W2086432763 @default.
• W2930082868 cites W2104893472 @default.
• W2930082868 cites W2107092156 @default.
• W2930082868 cites W2108593934 @default.
• W2930082868 cites W2146265197 @default.
• W2930082868 cites W2153727702 @default.
• W2930082868 cites W2155892228 @default.
• W2930082868 cites W2164453868 @default.
• W2930082868 cites W2167551217 @default.
• W2930082868 cites W2184842295 @default.
• W2930082868 cites W2192335107 @default.
• W2930082868 cites W2227011002 @default.
• W2930082868 cites W2231380722 @default.
• W2930082868 cites W2314990747 @default.
• W2930082868 cites W2335573103 @default.
• W2930082868 cites W2342741628 @default.
• W2930082868 cites W2468006215 @default.
• W2930082868 cites W2481919193 @default.
• W2930082868 cites W2590586437 @default.
• W2930082868 cites W2619312599 @default.
• W2930082868 cites W2769885370 @default.
• W2930082868 cites W932250880 @default.
• W2930082868 doi "https://doi.org/10.1016/j.talanta.2019.03.092" @default.
• W2930082868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31122403" @default.
• W2930082868 hasPublicationYear "2019" @default.
• W2930082868 type Work @default.
• W2930082868 sameAs 2930082868 @default.
• W2930082868 citedByCount "9" @default.
• W2930082868 countsByYear W29300828682020 @default.
• W2930082868 countsByYear W29300828682021 @default.
• W2930082868 countsByYear W29300828682022 @default.
• W2930082868 crossrefType "journal-article" @default.
• W2930082868 hasAuthorship W2930082868A5008405013 @default.
• W2930082868 hasAuthorship W2930082868A5011339475 @default.
• W2930082868 hasAuthorship W2930082868A5037096872 @default.
• W2930082868 hasAuthorship W2930082868A5054418515 @default.
• W2930082868 hasAuthorship W2930082868A5064642859 @default.
• W2930082868 hasConcept C10390740 @default.
• W2930082868 hasConcept C105795698 @default.
• W2930082868 hasConcept C113196181 @default.
• W2930082868 hasConcept C118663420 @default.
• W2930082868 hasConcept C145148216 @default.
• W2930082868 hasConcept C162356407 @default.
• W2930082868 hasConcept C165838908 @default.
• W2930082868 hasConcept C178790620 @default.
• W2930082868 hasConcept C185592680 @default.

• next